Alexei Degterev, PhD


Associate Professor of Developmental, Molecular & Chemical Biology



BS, Chemistry, Moscow State University
MS, Biochemistry, Moscow State University
PhD, Biochemistry, Boston University
Postdoctoral Training, Harvard Medical School


Campus: Boston
Office: M&V716B
Laboratory: Arnold 709

Contact Information

Office Phone: 617-636-0491
Lab Phone: 617-636-0495
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology, Neuroscience, Pharmacology


Research Synopsis

My lab focuses on the investigation of the molecular mechanisms, physiologic and pathophysiological roles of regulated cell death. Regulated cell death comes in many forms from apoptosis to a rapidly expanding spectrum of non-apoptotic necrosis-like cell death mechanisms. These processes play critical roles during development and in adult organism homeostasis, for example, helping eliminate infected, damaged or transformed cells. Conversely, alterations in regulated cell death pathways lead to a variety of human pathologies from acute traumas and ischemia-reperfusion injuries to cancer and chronic inflammatory diseases. The major aims of our work are to understand how key players in these pathways mediate activation of cell death in different contexts, especially as part of protective innate immune responses, and to develop chemical probes and drug leads that can be used to interrogate and therapeutically modulate cell death processes.


Lab Members

Bing Dai, MS Student in Pharmacology & Drug Development Send an e-mail Lab Research Page
Kerem Gurol, MS Student in Pharmacology & Drug Development Send an e-mail Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research