Alexander Poltorak, PhD

Alexander Poltorak, PhD

Associate Professor of Integrative Physiology & Pathobiology



BS, Chemistry, St Petersburg University
PhD, Chemistry, Technological Institute
Postdoctoral Training, University of Texas Southwestern Medical Center


Campus: Boston
Office: Jaharis 529A
Laboratory: Jaharis 527

Contact Information

Office Phone: 617-636-3596
Lab Phone: 617-636-3945
E-mail   Send an e-mail 


Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Genetics, Immunology, Molecular Microbiology


Research Synopsis

We focus on identifying the genes involved in the innate immune response and identifying the molecular pathway by which they act. We use mouse genetics and wild-derived strains of mice and focus on components of Toll-receptor signaling. Our recent work has uncovered novel ways by which host genes regulate inflammation, a response that can be protective, or when uncontrolled can result in septic shock and other serious diseases.


Lab Members

Bridget Larkin, Postdoctoral Scholar Send an e-mail  Lab Research Page
Caitlin Liu, MERGE-ID PhD Student in Immunology Send an e-mail  Lab Research Page
Hayley Muendlein, PhD Student in Genetics Send an e-mail Lab Research Page
Joe Sarhan, MD, PhD Student in Immunology Send an e-mail  Lab Research Page
Irina Smirnova, Research Associate Send an e-mail  Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research