Aimee Shen, PhD


Assistant Professor of Molecular Biology & Microbiology



BSc, Microbiology, University of Alberta
PhD, Microbiology, Harvard University
Postdoctoral Training, Stanford University


Campus: Boston
Office: M&V 409A
Laboratory: M&V 409

Contact Information

Office Phone: 617-636-3792
Lab Phone: 617-636-3798
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications 

Graduate Programs

Molecular Microbiology 


Research Synopsis

Clostridium difficile causes ~500,000 infections each year and is the leading cause of antibiotic-associated diarrhea and gastroenteritis-associated death in the United States. We study how C. difficile forms infectious spores and how these spores germinate upon sensing specific bile salts in the mammalian gut. Spore formation and germination are essential for C. difficile to transmit disease, and analyses of these processes have revealed major differences relative to previously studied spore formers. We use a multi-disciplinary approach to identify regulators of these processes and elucidate their mechanisms of action. A better understanding of the basic biology of C. difficile sporulation and spore germination should facilitate the development of spore-specific therapies that can prevent C. difficile disease transmission.


Lab Members

Hector Benito de la Puebla, Research Technician Send an e-mail
Oscar Diaz, PREP Scholar Send an e-mail Lab Research Page
Amy Rohlfing, Postdoctoral Scholar Send an e-mail Lab Research Page
Megan Touchette, Postdoctoral Scholar Send an e-mail Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research