Simran Kaushal


Simran Kaushal
BS, Biology
University of Maryland - College Park
College Park, MD
PhD Student in Biology
Catherine Freudenreich, PhD, Adviser





Metaphase chromosomes exposed to replication stress consistently show gaps and breaks at certain regions. These regions are called common fragile sites and are found in all individuals and conserved across species. Although they are evolutionarily persistent, common fragile sites are vulnerable points of the genome: they are the sites of rearrangements, translocations, and loss of heterozygosity in many cancers. Despite multiple theories, the molecular basis of common fragile site fragility is not well understood. I am studying human common fragile site FRA16D in yeast to better characterize the molecular basis behind common fragile site fragility.

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