Emily Newman

Emily Newman
BS, Psychology
Tufts University
Medford, MA
PhD Student in Experimental Psychology
Klaus Miczek, PhD, Adviser 

 

 

 

My research aims to clarify the role of NMDA and GABAA receptors in the escalation of aggression by alcohol and benzodiazepines. Animals self-administer a moderate dose of alcohol and aggressive behavior is evaluated using the resident-intruder paradigm. NMDA or GABAA receptor agonists or antagonists are administered following self-administration to determine their impact on alcohol-heightened aggression. Benzodiazepine-escalated aggression is evaluated using benzodiazepine-insensitive GABAA α1, α2, or α3 receptor knock-in mutants and their wild-type C57BL/6J counterparts. Mutant and wild type animals are administered doses of midazolam preceding evaluation of aggressive behavior in the resident-intruder paradigm. We aim to determine which alpha subunits are necessary for the disinhibiting effects of benzodiazepines.

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