Zhiyi Cao


Zhiyi Cao 
MS, Medical Science 
China Medical University
Shenyang, PRC
MD, Inner Mongolia Medical College
Hohhot, Inner Mongolia, China  
Research Associate
Noorjahan Panjwani, PhD, Adviser



I am investigating the role of a mannose-binding protein (MBP) in the pathogenesis of corneal infection produced by a virulent parasite, Acanthamoeba. I have demonstrated that amoebae express a transmembrane MBP which mediates the adhesion of the parasite to the surface of corneal epithelium and that subsequent to the adhesion, amoebae secrete a cytotoxic metalloproteinase. These proteinases are responsible for causing devastating damage to the cornea. My current studies are focused on  charactering the molecular mechanism by the carbohydrate-mediated host-parasite interactions lead to the secretion of cytotoxic proteinases.  

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