BSc, Biology, Zoology & Chemistry
India Institute of Technology
PhD, Molecular Biology
Institute of Medical Technology
Tata Institute of Fundamental Research
Honorine Ward, MBBS, Adviser
gp40 and gp900 are mucin-like Cryptosporidium glycoproteins that mediate Cryptosporidium infection in vitro. These glycoproteins contain mucin-type O-glycans that have exposed Gal(β1-3)GalNAc and/or GalNAc(α1-3)-Ser/Thr residues. A monoclonal antibody, 4E9 that recognizes these residues blocks attachment and invasion in vitro, implicating these glycans in mediating infection. My first project is focused on identification and characterization of the glycotope/s recognized by 4E9. I am currently mapping the 4E9 glycotope on gp40 using several complementary approaches. The long term goal is to determine whether these glycotopes can serve as immunogens for vaccine development or passive immunotherapy of cryptosporidiosis. In a second project, I am characterizing and investigating the role of a Cryptosporidium mucin-like protein with a C-type lectin domain.
Back to the Ward Profile Page