Najma Bhat


Najma Bhat 
BSc, Chemisty
MSc, Biochemistry
PhD, Biochemistry 
Aligarh Muslim University
Aligarh, India 
Research Associate
Honorine Ward, MBBS, Adviser


Cryptosporidium sporozoite attachment to epithelial cells and subsequent invasion are crucial events in the establishment of an infection. My work focuses on the way carbohydrate-mediated interaction of sporozoites with host cells is mediated and on the enzymes involved in mucin-type O-glycosylation of the pathogen-encoded glycoproteins. I have cloned, expressed and characterized a Gal/GalNAc-specific lectin, Cp30 that binds to glycoconjugates on host cells as well as on the parasite and shown that Gal/GalNAc-containing molecules, especially mucins and mucin-like proteins on the host cell and sporozoite surface are involved in mediating attachment. In addition, I have cloned and partially characterized polypeptide N-acetyl galactosaminyl transferases and am determining their role in mucin-type O-glycosylation of Cryptosporium glycoproteins.

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