Martin Ma


Martin Ma
BS, Biochemistry
Tufts University
Medford, MA
Research Technician
Giuseppina Tesco, MD, PhD, Adviser





Alzheimer’s disease (AD) is a neurodegenerative disorder that has been the leading cause of dementia in the population. The pathophysiological hallmark of AD is the accumulation of beta amyloid (Aβ) in brain. The activity of Beta-site APP Cleaving Enzyme 1 (BACE1) has been shown as the rate-limiting step in the molecular pathway that leads to Aβ production. Tesco Lab has shown that Golgi-localized γ-ear-containing ADP-ribosylation factor binding protein 3 (GGA3) regulates BACE1 level in in vitro model. My project explores the in vivo regulatory role of GGA3 on BACE1 using transgenic mice model. I cooperate with Dr. WonHee Kim on my research.

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