Carolyn Kramer


Carolyn Kramer
BS, Biology
Cornell University
Ithaca, NY
PhD, Biology
University of Memphis
Memphis, TN
Research Associate
Caroline Genco, PhD, Adviser



I am investigating the direct and indirect contributions of Porphyromonas gingivalis-induced inflammation to the development and progression of periodontal disease, atherosclerosis, pancreatic cancer, and oral cancers. Interleukin-1 (IL-1) is an important mediator of the pro-inflammatory response to pathogens.  I am interested in the role of IL-1 signaling on oral inflammatory bone loss and atherosclerotic plaque progression in response to the oral pathogen, P. gingivalis. Specifically, the divergent roles of IL-1alpha and IL-1beta in local vs. systemic inflammation will be defined. I am also investigating the genome-wide gene expression changes in aorta of mice subjected to three separate inducers of atherosclerosis: Porphyromonas gingivalis, Chlamydophila pneumoniae, and high-fat diet. Additionally, I am  also interested in the effects of the microbiome on the disease processes that the lab studies.

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