BPharm, Pharmaceutical Science
PhD, North Dakota State Univeristy
Stephen Moss, PhD, Adviser
Extrasynaptic GABAA receptors mediate tonic inhibition and play an important role in regulating neuronal excitability. My research goals are focused on the development of novel therapeutic targets for the treatment of neurological disorders involving aberrant tonic inhibition. Extrasynaptic GABAA receptors may be the potential candidates for therapeutic treatment in range of neurological disorders such as fragile X mental retardation, γ-hydroxybutyric acid (GHB)-uria, stress, disorders associated with menstrual cycle and puberty, and idiopathic generalized and temporal lobe epilepsies. Utilizing electrophysiological techniques, my ongoing work is to examine the properties of recombinant and native extrasynaptic GABAA receptors with special emphasis on α4 and δ subunits and their preferential targeting by endogenous and clinically relevant agents.
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