Tomas Blanco

Tomas

Tomas Blanco
BCH, Biochemistry
BS, Biological Sciences
University of Salamanca
Salamance, Spain
MSc, Vision Sciences
University of Valladolid
Valladolid, Spain
PhD,  Medicine
IOBA, University of Valladolid, Spain
Postdoctoral Scholar
Pedram Hamrah, MD, Adviser

 

 

With almost 30% of the population affected, dry eye disease (DED) is an ocular surface disorder showing instability of the tear film, inflammation, nerve degeneration and comorbid pain. The instability of the tear film increases tear osmolality and consequently results in desiccation, which induces epithelial injury with transient nerve degeneration, release of pro-inflammatory mediators, subsequent chronic corneal inflammation and often corneal neuralgia. The neuropathic pain is originated by central sensitization as the result of the ongoing damage to peripheral sensory neurons and by focally released pro-inflammatory mediators. The chronic release of inflammatory molecules results in modified ion channels distribution and altered neuronal properties that modulate the excitability of nociceptor terminals. The damage of the corneal nerves and the altered immune profile also provoke changes in the vascular system of the ocular surface. My research focuses in investigate the underlying crosstalk between nervous, immune and vascular systems in the ocular surface and search for new therapeutic approaches to treat neuropathic pain.

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December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research