Sylvia Lombardo

Sylvia

Sylvia Lombardo
MS, Biotechnology
La Sapienza University
Rome, Italy
PhD, Neuroscience
Institut Pasteur
Paris, France
Postdoctoral Scholar
Giuseppina Tesco, MD, PhD, Adviser

 

Alzheimer’s disease (AD) is a complex neurodegenerative disease influenced by both genetic and environmental factors. Traumatic brain injury (TBI) was identify as one of the main environmental risk factors for AD. Recently, the Tesco Lab demonstrated increased levels of BACE1, the enzyme responsible for cleaving amyloid precursor protein (APP) to initiate the production of beta amyloid (Ab) in mice brain following experimental TBI. BACE1 overexpression could lead to an increased Ab synthesis and then to dementia. My project focuses on investigating the role of BACE1 in TBI using transgenic murine models.

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research