La Sapienza University
Giuseppina Tesco, MD, PhD, Adviser
Alzheimer’s disease (AD) is a complex neurodegenerative disease influenced by both genetic and environmental factors. Traumatic brain injury (TBI) was identify as one of the main environmental risk factors for AD. Recently, the Tesco Lab demonstrated increased levels of BACE1, the enzyme responsible for cleaving amyloid precursor protein (APP) to initiate the production of beta amyloid (Ab) in mice brain following experimental TBI. BACE1 overexpression could lead to an increased Ab synthesis and then to dementia. My project focuses on investigating the role of BACE1 in TBI using transgenic murine models.
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