Spencer Fenn

spencer

Spencer Fenn
BSc, Biomedical Materials
University of Manchester
Manchester, United Kingdom
PhD, Bioengineering & Biomedical Engineering
University of Vermont
Burlington, VT
Postdoctoral Scholar
Lauren Black, PhD, Advisor

 

 

My research seeks to gain a greater understanding of the complex relationship between mechanical, matrisomal, and bioelectric signaling and how these cues can be utilized to alter the plasticity, differentiation & proliferation of patient-derived cardiac progenitor cells. We hope to exploit these resident progenitor cells in tissue engineering applications, by gaining control over their fate, and directing their differentiation towards specific cardiac lineages. To accomplish this, I utilize biomaterial substrates and scaffolds with tunable mechanics, and incorporated extracellular matrix components, while simultaneously modulating cell membrane potential, to assess alterations in gene and protein expression. It is hoped that this information can then be utilized to direct the repair and remodeling of functional cardiac tissues after injury, such as myocardial infarction, or in the event of tissue malformations such as congenital heart defects.

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research