Sirisha Mukkavalli


Sirisha Mukkavalli
BTech, Biotechnology
Jawaharlal Nehru Technological University, Hyderabad, India
MS, PhD, Biomedical Engineering & Biotechnology
University of Massachusetts - Dartmouth
Dartmouth, MA
Postdoctoral Scholar
Malavika Raman, PhD, Adviser



Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the prevalence of ubiquitin positive cellular aggregates, termed stress granules. A significant number of ALS causative genes including valosin containing protein (VCP), are linked to stress granule proteins and mutations result in the accelerated formation of stress granules. VCP mutations that cause ALS have been reported to interfere stress granule disassembly by autophagy, however the mechanisms that govern this important process are poorly understood. The goal of my work is to unravel the relationship between VCP and the stress granule life cycle.

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