Selene Lomoio

selene

Selene Lomoio
BSc, Biomedical Sciences
MSc, Neurobiology
University of Pavia
Pavia, Italy
PhD, Cell Biology
University of Pavia
Pavia, Italy
Institute of Neuropathology, IDIBELL
Barcelona, Spain
Postdoctoral Scholar
Giuseppina Tesco, MD, PhD, Adviser

 

 

Alzheimer’s disease (AD) is a neurodegenerative pathology clinically characterized by cognitive decline and changes in behavior and personality. BACE1 is the sole enzyme responsible for cleaving amyloid precursor protein (APP) to initiate the production of beta amyloid (Ab) peptides and oligomers in AD. Some studies propose that high BACE1 levels in AD are due to alteration of its metabolism as a consequence of abnormal cellular trafficking and sorting. Recently, the Tesco Lab described that GGA3 adaptor protein can modulate BACE1 trafficking to the lysosome. My project focuses on BACE1 trafficking to axons and dendrites in neuronal cultures models using a live cell imaging approach.

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research