University of Minnesota - Twin Cities
MPh, PhD, Neuroscience
New Haven, CT
Michele Jacob, PhD, Adviser
Autism spectrum disorder (ASD) and intellectual disability (ID) are two highly comorbid neurodevelopmental disorders which are thought to have overlapping etiologies. Individuals with reduced function for β-catenin, a critical synaptic adhesion protein and Wnt-signaling member, have been shown to have a higher risk for the development of both ASD and ID. Using a brain-specific β-catenin knockout mouse model, my research explores the neural basis of ASD and ID by examining the circuitry and plasticity changes caused by reduced β-catenin function in the brain.
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