MS, Behavioral Neuroscience
PhD, Addiction Neuroscience
Indiana University - Purdue University - Indianapolis
Jamie Maguire, PhD, Adviser
Stress can disrupt the brain's homeostatic balance of inhibitory and excitatory regulation. The Maguire lab is working to understand the role that dysregulation of the GABA receptor system-the brain's major inhibitory neurotransmitter system-plays in the development and expression of various pathologies. As a member of Dr. Maguire's research team, I am investigating the mechanisms underlying the effects of stress on reproductive health. Processes such as ovulation and pubertal onset are regulated by hormones whose synthesis and release are under tight inhibitory control. We hypothesize that stress hormones can disrupt the normal tonic inhibition of reproductive hormones at the level of the hypothalamus, to instigate a host of negative effects on reproduction. I am also interested in understanding how the body takes advantage of this interaction of stress and reproductive hormones to increase stress resilience during times like mid-to late pregnancy. The ultimate goal of this work is to identify potential pharmacological targets to improve the prognosis of various stress-related pathologies.
As part of the TEACRS Program, I am teaching a new course on brain-based sex differences this fall in the Honors College at UMass - Boston
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