Erica Polleys

erica

Erica Polleys
BA, Biology
Suffolk University
Boston, MA
PhD, Cell, Cell/Cellular & Molecular Biology
Baylor College of Medicine
Houston, TX
Postdoctoral Scholar
Catherine Freudenreich, PhD, Adviser

 

 

Elucidating the mechanisms behind CAG repeat instability is essential to understanding the general mechanisms of DNA repair as well as human disease, as CAG repeat expansions cause several severe genetic disorders which include Huntington’s disease and myotonic dystrophy. Recent work from the Freudenreich lab and others has shown that homologous recombination (HR) results in CAG repeat expansions, and I am particularly interested in utilizing the S. cerevisiae yeast model system to determine how this occurs. To address this, I am working to develop a new system to study CAG repeat instability during sister chromatid recombination, a subtype of HR. Additionally, I am interested in how histone modifications, particularly acetylation of histone H4, influence HR fidelity and CAG repeat stability.

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December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research