PhD, Cell, Cell/Cellular & Molecular Biology
Baylor College of Medicine
Catherine Freudenreich, PhD, Adviser
Elucidating the mechanisms behind CAG repeat instability is essential to understanding the general mechanisms of DNA repair as well as human disease, as CAG repeat expansions cause several severe genetic disorders which include Huntington’s disease and myotonic dystrophy. Recent work from the Freudenreich lab and others has shown that homologous recombination (HR) results in CAG repeat expansions, and I am particularly interested in utilizing the S. cerevisiae yeast model system to determine how this occurs. To address this, I am working to develop a new system to study CAG repeat instability during sister chromatid recombination, a subtype of HR. Additionally, I am interested in how histone modifications, particularly acetylation of histone H4, influence HR fidelity and CAG repeat stability.
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