Rensselaer Polytechnic Institute
PhD, Cell, Molecular & Developmental Biology
Sackler School, Tufts University
James Schwob, MD, PhD, Adviser
Our lab works on the pseudostratified olfactory epithelium (OE) which consists of olfactory sensory neurons, glial-like sustentacular cells, and basal stem cells. This tissue continually undergoes a remarkable amount of adult neurogenesis to replace neurons lost due to environmental factors as well as natural turnover.
The OE is an attractive model to study the underlying principles of neural regeneration as well as a potential source for neural stem cell therapies. Key to both of these endeavors is understanding the fate decisions of these stem cells. I am interested in neural commitment and how the standard cascade of neurogenic transcription factors may actually be very plastic. Key to my studies are transplantation assays and CRISPR-mediated mouse generation, as well as Gibson facilitated molecular biology.
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