Sackler School, Tufts University
Jamie Maguire, PhD, Adviser
Corticotropin-releasing hormone (CRH) is a critical component in the signaling pathways that allow the body to respond to stress. While CRH is usually discussed in the context of the paraventricular nucleus of the hypothalamus, there are several other groups of neurons which express CRH but whose roles in mediating the stress response are less well understood. I am investigating a population of such neurons in the CA1 region of the hippocampus to determine what areas of the brain they innervate, from where they receive input, and their role in mediating the hypothalamic-pituitary-adrenal axis response to stress.
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