Student Publications

2017


Cao L, Kwara A, Greenblatt DJ. 2017. Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. Epub ahead of print.   books

Cao L, Greenblatt DJ, Kwara A. 2017. Inhibitory effects of selected antituberculosis drugs on common human hepatic cytochrome P450 and UDP-glucuronosyltransferase enzymes. Drug Metab Dispos. Epub ahead of print.  books

Du C, Collins W, Cantley W, Sood D, Kaplan DL. 2017. Tutorials for electrophysiological recordings in tissue engineering. ACS Biomaterials Science & Engineering. Abstract in PubMed

Nwankwo JO, Gremmel T, Gerrits AJ, Mithila FJ, Warburton RR, Hill NS, Lu Y, Richey LJ, Jakubowski JA, Frelinger AL 3rd, Chishti AH. 2017. Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease. Thromb Res. 160: 58-65.  books

Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. 2017. Kinase activities of RIPK1 and RIPK3 can direct IFN-β synthesis induced by lipopolysaccharide. J Immunol. 198: 4435-4447.  books

Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. 2017. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci USA Epub ahead of print.   Abstract in PubMed

2016


Julian B, Gao K, Harwood BN, Beinborn M, Kopin AS. 2016. Mutation-induced functional alterations of CCR6. J Pharmacol Exp Ther. 360: 106-116.  books

Lu Y, Hanada T, Fujiwara Y, Nwankwo JO, Wieschhaus AJ, Hartwig J, Huang S, Han J, Chishti AH. 2016. Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood. 128: 93-103.  books

Najjar M*, Saleh D*, Zelic M, Nogusa S, Shah A, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen M, Pasparakis, Balachandran S, Kelliher M, Poltorak A, Degterev A. 2016. RIPK1 and RIPK3 kinases promote cell death-independent inflammation by TLR4-TRIF Immunity. 45: 46-59. * equal contribution. books

Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. 2016. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica. 101: e397-e400.  books

Szabo R, Lantsman T, Peters DE, Bugge TH. 2016. Delineation of proteolytic and non-proteolytic functions of membrane-anchored serine protease Prss8/prostasin. Development 143: 2818-2828. Abstract in PubMed

Theoharides TC, Stewart JM, Taracanova A, Conti P, Zouboulis CC. 2016. Neuroendocrinology of the skin. Rev Endocr Meab Disorders. 17: 287-294.  Abstract in PubMed

Weng Z, Zhang B, Tsilioni I, Theoharides TC. 2016. Nanotube formation: A rapid form of "alarm signaling"? Clin Ther. 38: 1066-1072.   Abstract in PubMed

2015


Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. 2015. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc Natl Acad Sci USA 112: 3463-3468. books

Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. 2015. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Rep. 10: 1850-1860. books

Theoharides TC, Petra AI, Taracanova A, Panagiotidou S, Conti P. 2015. Targeting IL-33 in autoimmunity and inflammation. J Pharmacol Exp Ther. 354: 24-31. Abstract in PubMed

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. 2015. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci USA 112: 14805-14810. books

Wein AN, Peters DE, Valivullah Z, Hoover BJ, Tatineni A, Ma Q, Fattah R, Bugge TH, Leppla SH, Liu S. 2015. An anthrax toxin variant with an improved activity in tumor targeting. Sci Rep. 5: 16267. books

Weng Z, Patel AB, Panagiotidou S, Theoharides TC. 2015. The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J Allergy Clin Immunol. 135: 1044-1052. Abstract in PubMed

2014


Abramian AM*, Comenencia-Ortiz E*, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ. 2014. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc Natl Acad Scie USA 111: 7132-7137. (* equal contribution) books

Alevizos M, Karagkouni A, Panagiotidou S, Vasiadi M, Theoharides TC. 2014. Stress triggers coronary mast cells leading to cardiac events. Ann Allergy Asthma Immunol. 112: 309-316. Abstract in PubMed

Fiaturi N, Castellot JJ Jr, Nielsen HC. 2014. Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review. J Cell Commun Signal. 8:105-111. Abstract in PubMed

Fiaturi N, Ritzkat A, Dammann CE, Castellot JJ, Nielsen HC. 2014. Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation. Biochim Biophys Acta 1843: 797-805. Abstract in PubMed

Miniati A, Weng Z, Zhang B, Therianou A, Vasiadi M, Nicolaidou E, Stratigos AJ, Antoniou C, Theoharides TC. 2014. Stimulated human melanocytes express and release interleukin-8, which is inhibited by luteolin: relevance to early vitiligo. Clin Exp Dermatol. 39: 54-57.  Abstract in PubMed

Peters DE, Hoover B, Cloud LG, Liu S, Molinolo AA, Leppla SH, Bugge TH. 2014. Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities. Toxicol Appl Pharmacol. 279: 220-229. Abstract in PubMed

Peters DE, Szabo R, Friis S, Shylo NA, Uzzun Sales K, Holmbeck K, Bugge TH. 2014. The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity. J Biol Chem 289: 14740-14749.  Abstract in PubMed

Szabo R, Peters DE, Kosa P, Camerer E, Bugge TH. 2014. Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 10: e1004470.  Abstract in PubMed

Vasiadi M, Newman J, Theoharides TC. 2014. Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome. J Neuroinflammation 11: 168. Abstract in PubMed

Weng Z, Patel AB, Vasiadi M, Therianou A, Theoharides TC. 2014. Luteolin inhibits human keratinocyte activation and decreases NF-κB induction that is increased in psoriatic skin. PLoS One 9: e90739. Abstract in PubMed

2013


Alevizos M, Karagkouni A, Vasiadi M, Sismanopoulos N, Makris M, Kalogeromitros D, Theoharides TC. 2013. Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. Ann Allergy Asthma Immunol. 111: 542-547. Abstract in PubMed

Friis S, Uzzun Sales K, Godiksen S, Peters DE, Lin CY, Vogel LK, Bugge TH. 2013. A matriptase-prostasin reciprocal zymogen activation complex with unique features: Prostasin as a non-enzymatic co-factor for matriptase activation. J Biol Chem. 288: 19028-19039. Abstract in PubMed

Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. 2013. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 75: 1041-1052. Abstract in PubMed

Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. 2013. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 202: 951-966.   Abstract in PubMed

Oakes B, Hoagland-Henefield M, Komaroff AL, Erickson JL, Huber BT. 2013. Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients. Clin Infect Dis. 56: 1394-1400. books

Theoharides TC, Asadi S, Panagiotidou S, Weng Z. 2013. The "missing link" in autoimmunity and autism: extracellular mitochondrial components secreted from activated live mast cells. Autoimmune Rev. 12: 1136-1142. Abstract in PubMed

Vasiadi M, Mondolfi AP, Alysandratos KD, Therianou A, Katsarou-Katsari A, Petrakopoulou T, Theoharidis A, Miniati A, Theoharides TC. 2013. Neurotensin serum levels and skin gene expression are increased in atopic dermatitis. Br J Dermatol. 169: 695-699. Abstract in PubMed

Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH. 2013. Effect of an herbal extract containing curcumin and piperine on midazolam, flurbiprofen, and acetaminophen pharmacokinetics in healthy volunteers. Br J Clin Pharmacol. 75: 450-462. Abstract in PubMed

2012


Allen PJ, Batra P, Geiger BM, Wommack T, Gilhooly C, Pothos EN. 2012. Rationale and consequences of reclassifying obesity as an addictive disorder: Neurobiology, food environment and social policy perspectives. Physiol Behav. 107: 126-137. Abstract in PubMed

Asadi S, Alysandratos KD, Angelidou A, Miniati A, Sismanopoulos N, Vasiadi M, Zhang B, Kalogeromitros D, Theoharides TC. 2012. Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells. J Invest Dermatol. 132: 324-329. Abstract in PubMed 

Greenblatt DJ, Zhao Y, Hanley MJ, Chen C, Harmatz JS, Cancalon PF, Gmitter FG Jr. 2012. Mechanism-based inhibition of human Cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content. Xenobiotica. 42: 1163-1169. Abstract in PubMed

Hanley MJ, Masse G, Harmatz JS, Court MH, Greenblatt DJ. 2012. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: Divergence from in vitro results. Clin Pharmacol Ther. 92: 651-657. Abstract in PubMed

Miniati A, Weng Z, Zhang B, Stratigos AJ, Nicolaidou E, Theoharides TC. 2012. Neuro-immuno-endocrine processes in vitiligo pathogenesis. Int J Immunopathol Pharmacol. 25: 1-7 Abstract in PubMed

Peters DE, Zhang Y, Molinolo AA, Miller-Randolph S, Szabo R, Bugge TH, Leppla SH, Liu S. 2012. Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis. Biochem Biophys Res Commun. 422: 393-397. Abstract in PubMed

Sismanopoulos N, Delivanis DA, Alysandratos KD, Angelidou A, Vasiadi M, Therianou A, Theoharides TC. 2012. IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis. PLoS One 7: e33271. Abstract in PubMed

Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. 2012. Mast cells and inflammation. Biochim Biophys Acta 7: 80. books

Umberg EN, Shader RI, Hsu LK, Greenblatt DJ. 2012. From disordered eating to addiction: the "food drug" in bulimia nervosa. J Clin Psychopharmacol. 32: 376-389. Abstract in PubMed

Vasiadi M, Therianou A, Sideri K, Smyrnioti M, Sismanopoulos N, Delivanis DA, Asadi S, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Antoniou C, Papadavid E, Stavrianeas N, Kalogeromitros D, Theoharides TC.  2012. Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis. J Allergy Clin Immunol. 129: 1410-1413. Abstract in PubMed

Vasiadi M, Therianou A, Alysandratos KD, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Papadavid E, Stavrianeas N, Antoniou C, Kalogeromitros D, Theoharides TC. 2012. Serum neurotensin (NT) is increased in psoriasis and NT induces VEGF release from human mast cells. Br J Dermatol. 166: 1349-1352. Abstract in PubMed

Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. 2012. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One 7: e33805. Abstract in PubMed

Zhang B, Asadi S, Weng Z, Sismanopoulos N, Theoharides TC. 2012. Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions. PLoS One 7: e49767. Abstract in PubMed

Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos KD, Angelidou A, Shirihai O, Theoharides TC. 2012. Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol. 159: 23-32. Abstract in PubMed

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December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research