Vaughn Youngblood

Vaughn

Vaughn Youngblood
BS, Pharmacy & Toxicology
Massachusetts College of Pharmacy
Boston, MA
MS Student in Pharmacology & Drug Development
David Greenblatt, MD, Adviser

 

 

 

I am investigating the metabolism of the active ingredient acetaminophen (APAP) [Tylenol] with a goal to reduce the formation of the toxic metabolite NAPQI from promoting liver toxicity. I use human liver microsomes as part of a cellular assay to mimic the conditions within the liver where metabolism occurs. During later steps of the project, I hope to use this assay to attempt to reproduce previous indications that both green tea extract and the active ingredient diethyldithiocarbamate (DDC) have an inhibitory effect on cytochrome P450 2E1 (CYP2E1), the enzyme responsible for APAP metabolism.

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