Sara Algeelani


Sara Algeelani
DPharm, Pharmacy
Kind Saud University
Riyadh, Saudi Arabia
MS Student in Pharmacology & Drug Development
David Greenblatt, MD, Adviser




Hepatic metabolism increases the polarity (water solubility) of drugs so that they can be easily excreted form the body. Some drugs undergo either phase I (oxidation, reduction, and hydroxylation) or phase ll (Conjugation) metabolism. However, the majority undergo phase l followed by phase ll, thereby Phase ll metabolism detoxify the reactive metabolite of phase l metabolism. Canagliflozin, a sodium-dependent glucose transport 2 (SGLT2) inhibitor, is an innovative drug approved to treat adults with type 2 diabetes mellitus. Phase ll glucuronidation reaction is the major metabolic elimination pathway for canagliflozin. I am testing the possible inhibitory effect of other anti-diabetic drugs on the metabolism of canagliflozin. Using an in vitro system with human liver microsomes (HLMs), I'm studying the inhibition profile of uridine 5'-diphospho-glucuronosyltransferases (UGTs) isoenzymes which are the major metabolizing enzymes that catalyze phase II biotransformation reactions.

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