Nicholas Jackson


Nicholas Jackson
BA, Biology & Psychology
Framingham State College
Framingham, MA
MS Student in Pharmacology & Drug Development
Amy Yee, PhD, Adviser




Patients with ulcerative colitis (UC) have an increased risk of developing colitis-associated colorectal cancer (CAC), which is characterized differently from the typical colorectal cancer. The progression from UC to CAC is not well understood, thus warranting new studies on the UC and CAC progression. HBP1 is a transcriptional repressor that has been shown to suppress WNT signaling. HBP1 knockout mice have shown an increased susceptibility to UC as well as signs of CAC progression. My project is targeted towards understanding HBP1 and its influences on UC and CAC. By using the labs HBP1 knockout mouse model, we hope to better understand the molecular mechanisms contributing to these previous findings.

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December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

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