Fernando Senjobe

fernando

Fernando Senjobe
Associate Degree, Biology
Bunker Hill Community College
Boston, MA
BS, Biology
University of Massachusetts - Boston
Boston, MA
PREP Scholar
James Munro, PhD, Adviser

 

 

 

Ebola virus (EBOV) is an enveloped virus that causes hemorrhagic fever in humans with high morbidity and mortality rates. The mechanism by which the EBOV envelope glycoprotein engages with the endosomal membrane protein Niemann-Pick type C1 (NPC1), which leads to fusion of the viral and cell membranes, is not fully understood. Although membrane fusion occurs at low pH in the late endosome, the role of pH in receptor binding and fusion is unclear. Using biochemical and biophysical techniques I am seeking to determine the role of low pH in the NPC1 binding reaction and activation of GP for membrane fusion. In particular we will develop fluorescence based kinetic assays to determine the rates of NPC1 binding and fusion as a function of pH.

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