Student Publications

2017


Coleman JH, Lin B, Schwob JE. 2017. Dissecting LSD1-dependent neuronal maturation in the olfactory epithelium. Comp Neurol. Epub ahead of print. books

Foley J, Blutstein T, Lee S, Erneux C, Halassa MM, Haydon P. 2017. Astrocytic IP3/Ca2+ signaling modulates theta rhythm and REM sleep. Front Neural Circuits 11:3.  Abstract in PubMed

Fuchs T, Jefferson SJ, Hooper A, Yee PP, Maguire J, Luscher B. 2017. Disinhibition of somatostatin-positive interneurons by deletion of postsynaptic GABAA receptors. Mol Psychiatry 22: 787. books

Papouin T, Dunphy J, Tolman M, Foley JC, Haydon PG. 2017. Astrocytic control of synaptic function. Philos Trans R Soc Lond B Biol Sci. 372 (1715). Abstract in PubMed

Papouin T, Dunphy JM, Tolman M, Dineley KT, Haydon PG. 2017. Septal cholinergic neuromodulation tunes the astrocyte-dependent gating of hippocampal NMDA receptors to wakefulness. Neuron Epub ahead of print. Abstract in PubMed

Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. 2017. Kinase activities of RIPK1 and RIPK3 can direct IFN-β synthesis induced by lipopolysaccharide. J Immunol. 198: 4435-4447.  books

Salzberg Y, Coleman A, Celestrin K, Cohen-Berkman M, Biederer T, Henis-Korenblit S, Bulow HE. 2017. Reduced Insulin/Insulin-like Growth Factor Receptor Signaling Mitigates Defective Dendrite Morphogenesis in Mutants of the ER Stress Senor IRE-1. PLoS Genet. 13: e1006579.  books

Wegner KW, Saleh D, Degterev A. 2017. Complex pathologic roles of RIPK1 and RIPK3: Moving beyond necroptosis. Trends Pharmacol Sci. 28: 202-225.  books

2016


Armbruster M, Hanson E, Dulla CG. 2016. Glutamate clearance is locally modulated by presynaptic neuronal activity in the cerebral cortex. J Neurosci. 36: 10404-10415.   Abstract in PubMed

Cairns DM, Chwalek K, Moore YE, Kelley MR, Abbott RD, Moss S, Kaplan DL. 2016. Expandable and rapidly differentiating human induced neural stem cell lines for multiple tissue Engineering applications. Stem Cell Rep. 7: 557-570. Abstract in PubMed

Clasadonte J, Morel L, Barrios-Camacho CM, Chiang MS, Zhang J, Iyer L, Haydon PG, Yang Y. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiol Dis. 91: 315-325. books

Hanson E, Danbolt NC, Dulla CG. 2016. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiol Dis. 89: 157-168.  Abstract in PubMed

Hooper A, Maguire J 2016. Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus 26: 41-53.   books

Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ. 2016. Compromising KCC2 transporter activity enhances the development of continuous seizure activity. Neuropharmacology. 108: 103-110. books

Kilinc S, Savarino A, Coleman JH, Schwob JE, Lane RP. 2016. Lysine-specific demethylase-1 (LSD1) is compartmentalized at nuclear chromocenters in early post-mitotic cells of the olfactory sensory neuronal lineage. Mol Cell Neurosci. 74: 58-70. books

Lee V, MacKenzie G, Hooper A, Maguire J. 2016. Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus. 26: 1276-1290. books

Modgil A, Parakala ML, Ackley MA, Doherty JJ, Moss SJ, Davies PA. 2016. Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism. Neuropharmacology 113(Pt A): 314-322.  books

Moss BJ, Park L, Dahlberg CL, Juo P. 2016. The CaM kinase CMK-1 mediates a negative feedback mechanism coupling the C. elegans glutamate receptor GLR-1 with its own transcription. PLoS Genet. 12: e1006180. Abstract in PubMed

Najjar M*, Saleh D*, Zelic M, Nogusa S, Shah A, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen M, Pasparakis, Balachandran S, Kelliher M, Poltorak A, Degterev A. 2016. RIPK1 and RIPK3 kinases promote cell death-independent inflammation by TLR4-TRIF Immunity. 45: 46-59. * equal contribution. books

Ng FS, Sengupta S, Huang Y, Yu AM, You S, Roberts MA, Iyer LK, Yang Y, Jackson FR. 2016. TRAP-seq profiling and RNAi-based genetic screens identify conserved glial genes required for adult Drosophila behavior. Front Mol Neurosci. 9: 146.  Abstract in PubMed

Pirone A, Alexander J, Lau LA, Hampton D, Zayachkivsky A, Yee A, Yee A, Jacob MH, Dulla CG. 2016. APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures. Neurobiol Dis. 98: 149-157.  Abstract in PubMed

Yeates EF, Tesco G 2016. The endosomal-associated deubiquitinating enzyme USP8 regulates BACE1 ubiquitination and degradation. J Biol Chem. 291:15753-15766. Abstract in PubMed

2015


Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. 2015. Inflammatory signaling by NOD-RIPK2 ss inhibited by clinically relevant type II kinase inhibitors. Chem Bio. pii: S1074-5521(15)00322-1. Abstract in PubMed

Cantu D, Walker K, Andresen L, Taylor-Weiner A, Hampton D, Tesco G, Dulla CG. 2015. Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic control. Cereb Cortex 25: 2306-2320. Abstract in PubMed

Cook-Snyder DR, Jones A, Reijmers LG. 2015. A retrograde adeno-associated virus for collecting ribosome-bound mRNA from anatomically defined projection neurons. Front Mol Neurosci. 8: 56. books

Garafalo SD, Luth ES, Moss BJ, Monteiro MI, Malkin E, Juo P. 2015. The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Mol Biol Cell 26: 1887-1900. Abstract in PubMed

Hanson E, Armbruster M, Cantu D, Andresen L, Taylor A, Danbolt NC, Dulla CG. 2015. Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Glia 63: 1784-1796. Abstract in PubMed

Hickman TT, Liberman MC, Jacob MH. 2015. Adenomatous polyposis coli protein deletion in efferent olivocochlear neurons perturbs afferent synaptic maturation and reduces the dynamic range of hearing. J Neurosci. 35: 9236-9245. books

Jackson FR, Ng FS, Sengupta S, You S, Huang Y. 2015. Glial cell regulation of rhythmic behavior. Methods Enzymol. 552: 45-73. books

Liu L, Peritore C, Ginsberg J, Shih J, Arun S, Donmez G. 2015. Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease. Behav Brain Res. 281: 215-221. books

McGehee AM, Moss BJ, Juo P. 2015. The DAF-7/TGF-β signaling pathway regulates abundance of the Caenorhabditis elegans glutamate receptor GLR-1. Mol Cell Neurosci. 67: 66-74. Abstract in PubMed

Metallo C, Trimmer BA. 2015. Orientation-dependent changes in single motor neuron activity during adaptive soft-bodied locomotion. Brain Behav Evol. 85: 47-62. books

Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. 2015. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Rep. 10: 1850-1860. books

Nakamura Y, Darnieder LM, Deeb TZ, Moss SJ. 2015. Regulation of GABAARs by phosphorylation. Adv Pharmacol. 72:97-146. books

Ng SK, Higashimori H, Tolman M, Yang Y 2015. Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. 267: 115-122. Abstract in PubMed

Saleh D, Degterev A. 2015. Emerging roles for RIPK1 and RIPK3 in pathogen-induced cell death and host immunity. Curr Topics Microbiol Immunol. Epub ahead of print.   books

Schnittke N, Herrick DB, Lin B, Peterson J, Coleman JH, Packard AI, Jang W, Schwob JE. 2015. Transcription factor p63 controls the reserve status but not the stemness of horizontal basal cells in the olfactory epithelium. Proc Natl Acad Sci USA 112: E5068-E5077.  books

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci USA 112: 3523-3528. books

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. 2015. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices in vitro and in vivo. J Neurosci. 35: 8291-8286. books

Uzturk BG, Jin SX, Rubin B, Bartolome C, Feig LA. 2015. Ras-GRF1 regulates the HPA axis specifically in early-adolescent female mice. J Endocrinol. 227: 227-238.  Abstract in PubMed

Wong LE, Gibson ME, Arnold HM, Pepinsky B, Frank E. 2015. Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush. Proc Natl Acad Sci USA 112: 6170-6175. books

2014


Abramian AM*, Comenencia-Ortiz E*, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ. 2014. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc Natl Acad Scie USA 111: 7132-7137. (* equal contribution) books

Ainsley JA, Drane L, Jacobs J, Kittelberger KA, Reijmers LG. 2014. Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience. Nat Commun. 5: 4510. books

Andresen L, Hampton D, Taylor A, Morel L, Yang Y, Maguire J, Dulla CG. 2014. Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Neurobiol Dis. 71: 305-316. Abstract in PubMed

Clasadonte J, McIver SR, Schmitt LI, Halassa MM, Haydon PG. 2014. Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci. 34: 1879-1891. books

Comenencia-Ortiz E, Moss SJ, Davies PA. 2014. Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions. Psychopharmacology (Berl) 231: 3453-3465. books

Cordeira JW, Felsted J, Teillon S, Daftary-Bussiere S, Wirth J, Sena-Esteves M, Rios M. 2014. Hypothalamic dysfunction of the calcium channel subunit underlies the overeating and obesity triggered by BDNF deficiency. J Neurosci. 34: 554-565. books

Drane L, Ainsley JA, Mayford MR, Reijmers LG. 2014. A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system. Front Mol Neurosci. 7: 82. books

Kowalski JR, Dube H, Touroutine D, Goodwin PR, Carozza M, Didier Z, Francis MM, Juo P. 2014. The anaphase-promoting complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction. Mol Cell Neurosci. 58:62-75. books

Lee V, Maguire J. 2014. The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type. Front Neural Circuits 8: 3. books

Lee V, Sarkar J, Maguire J. 2014. Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology 41: 75-88. books

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. New molecular insights into cognitive and autistic-like disabilities. Mol Psychiatry 19: 1053. books

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. Mol Psychiatry 19: 1133-1142. books

Morel L, Higashimori H, Tolman M, Yang Y. 2014. VGluT1+ neuronal glutamatergic signaling regulates postnatal developmental maturation of cortical protoplasmic astroglia. J Neurosci. 34: 10950-10962. Abstract in PubMed

O'Toole KK, Hooper A, Wakefield S, Maguire J. 2014. Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res. 108: 29-43. books

Shih J, Mason A, Liu L, Higashimori H, Donmez G. 2014. Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid. J Neurochem. 131: 573-581. books

2013


Goodwin PR, Juo P. 2013. The scaffolding protein SYD-2/Liprin-α regulates the mobility and polarized distribution of dense-core vesicles in C. elegans motor neurons. PLoS One 8: e54763. books

Hines DJ, Schmitt LI, Hines RM, Moss SJ, Haydon PG. 2013. Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl Psychiatry 3: e212. books

Lee V, Maguire J. 2013. Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol. 110: 2520-2535. books

Radner S, Banos C, Bachay G, Li YN, Hunter DD, Brunken WJ, Yee KT. 2013. β2 and γ3 laminins are critical cortical basement membrane components: ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia. Dev Neurobiol. 73: 209-229. books

Shih J, Donmez G. 2013. Mitochondrial sirtuins as therapeutic targets for age-related disorders. Genes Cancer 4: 91-96. books

Trouche S, Sasaki, JM, Tu T, Reijmers LG. 2013. Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses. Neuron 80: 1054-1065. Abstract in PubMed

2012


Goodwin PR, Sasaki JM, Juo P 2012.  Cyclin-dependent kinase-5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles (DCVs) in C elegans motor neurons.  J Neurosci. 32: 8158-8172. Abstract in PubMed

Jacob TC, Michels G, Silayeva L, Haydon J, Succol F, Moss SJ. 2012. Benzodiazepine treatment induces subtype-specific changes in GABAA receptor trafficking and decreases synaptic inhibition. Proc Natl Acad Sci USA 109: 18595-18600. books

Schmitt LI, Sims RE, Dale N, Haydon PG. 2012. Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine. J Neurosci. 32: 4417-4425. Abstract in PubMed

Tangredi MM, Ng FS, Jackson FR. 2012. The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior. J Biol Chem. 287: 16748-16758. Abstract in PubMed

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research