BA, Molecular Biology
MD, PhD Student in Molecular Microbiology
Carol Kumamoto, PhD, Adviser
Candida albicans is a microorganism that either can live as a commensal organism in the gastrointestinal (GI) tract of humans, or can become an opportunistic pathogen that can spread systemically and cause potentially fatal disease. The expression level of a particular C. albicans transcription factor, EFG1, which is known to be involved in a wide variety of the yeast's physiological transitions, has been shown to demonstrate distinct cell-to-cell variation within a single population. In in vivo studies with murine hosts, the average EFG1 levels expressed by wild-type C. albicans were found to vary significantly depending on the immune status of the murine host (eg, athymic mice vs immunocompetent mice), and also the number of days since C. albicans had been inoculated into the GI tract of the host. My project focuses on analysis of gene expression in C. albicans.
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