BS, Pharmaceutical Science
American University in Cairo
PhD Student in Molecular Microbiology - MERGE-ID
Joan Mecsas, PhD, Adviser
Polymorphonuclear neutrophils (PMNs) provide the first line of defense against invading microorganisms through a variety of mechanisms , however the signalling pathway that regulate the bactericidal responses of PMNs remains poorly understood. Yersinia pseudotuberculosis (Yptb) a gram negative enteric pathogen uses T3SS to inject effector proteins Yops to circumvent the defensive function of PMNs. I am interested in understanding how PMNs are manipulated by Yptb Yops to permit survival and growth.
YopH a tyrosine phosphatase that interferes with the phosphorylation of several adaptors and effectors impairs PMN responses to bacteria by interfering with SKAP2 dependent systems that coordinate bacterial functions of PMNs in response to different receptors. The aim of my project is to know how SKAP2 and other Yop-targeted proteins work in PMNs to control bactericidal responses to be able to unravel the signalling pathway which would provide insight into the molecular mechanisms regulating PMN function during infection.
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