Student Publications


Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J. 2018. A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerob Epub ahead of print. books


Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA 2017. Cytosolic phospholipase A2α promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection. Infect Immun. Epub ahead of print. books

Cokol M, Kuru N, Bicak E, Larkins-Ford J, Aldridge BB. 2017. Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis. Sci Adv. 3:e1701881. books

de Jesús-Díaz DA, Murphy C, Sol A, Dorer M, Isberg RR. 2017. Host cell S phase restricts Legionella pneumophila intracellular replication by destabilizing the membrane-bound replication compartment. MBio 8: e02345-16. books

Herwald SE, Zucchi PC, Tan S, Kumamoto CA.n 2017. The two transmembrane regions of Candida albicans Dfi1 contribute to its biogenesis. Biochem Biophys Res Commun. Epub ahead of print. books

Klein BA, Cornacchione LP, Collins M, Malamy MH, Duncan MJ, Hu LT. 2017. Using Tn-seq to identify pigmentation related genes of Porphyromonas gingivalis: Characterization of the role of a putative glycosyltransferase. J Bacteriol. Epub ahead of print.  books

Koenigsberg AL, Heldwein EE. 2017. Crystal structure of the N-terminal half of the traffic controller UL37 from Herpes Simplex virus Type 1. J Virol. Epub ahead of print. books

Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB. 2017. A parallel adder coordinates Mycobacterial cell-cycle progression and cell-size homeostasis in the context of asymmetric growth and organization. Curr Biol. 27: 3367-3374. books

Mann KM, Huang DL, Hooppaw AJ, Logsdon MM, Richardson K, Lee HJ, Kimmey JM, Aldridge BB, Stallings CL. 2017. Rv0004 is a new essential member of the mycobacterial DNA replication machinery. PloS Genet. 13: e1007115. books

Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM. 2017. Mechanisms of HERV-K (HML-2) transcription during human mammary epithelial cell transformation. J Virol. Epub ahead of print.  books

Nguyen GT, Green ER, Mecsas J. 2017. Neutrophils to the ROScue: Mechanisms of NADPH oxidase activation and bacterial resistance. Front Cell Infect Microbiol. 7:373. books

Richards AL, Sollars PJ, Pitts JD, Stults AM, Heldwein EE, Pickard GE, Smith GA. 2017. The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion. PLoS Pathog. 13: e1006741. books

Yen M, Cairns LS, Camilli A. 2017. A cocktail of three virulent bacteriophages prevents Vibrio cholerae infection in animal models. Nat Commun. 8: 14187. books


Curtis A, Blackburn JK, Smiley SL, Yen M, Camilli A, Alam MT, Ali A, Morris JG. 2016. Mapping to support fine scale epidemiological cholera investigations: A case study of spatial video in Haiti. Int J Environ Res Public Health 13 (2).  books

Fleming E, Camilli A. 2016. ManLMN is a glucose transporter and central metabolic regulator in Streptococcus pneumoniae. Mol Microbiol. 102: 467-487.  books

Flowers LJ, Bou Ghanem EN, Leong JM. 2016. Synchronous disease kinetics in a murine model for enterohemorrhagic E. coli infection using food-borne inoculation. Front Cell Infect Microbiol. 6:138.  books

Green ER, Clark S, Crimmins GT, Mack M, Kumamoto CA, Mecsas J. 2016. Fis is essential for Yersinia pseudotuberculosis virulence and protects against reactive oxygen species produced by phagocytic cells during infection. PLoS Pathog. 12: e1005898.   books

Hawver LA, Jung SA, Ng WL. 2016. Specificity and complexity in bacterial quorum-sensing systems. FEMS Microbiol Rev. 40: 738-752. books

Jung SA, Hawver LA, Ng WL. 2016. Parallel quorum sensing signaling pathways in Vibrio cholerae. Curr Genet. 62: 255-260. books

Khaperskyy DA, Schmaling S, Larkins-Ford J, McCormick C, Gaglia MM. 2016. Selective degradation of host RNA polymerase II transcripts by influenza A virus PA-X host shutoff protein. PLoS Pathog. 12: e1005427.  Abstract in PubMed

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe. 21: 169-181. books

McDonough E, Kamp H, Camilli A. 2016. Vibrio cholerae phosphatases required for the utilization of nucleotides and extracellular DNA as phosphate sources. Mol Microbiol. 99: 453-469.  books

Tyc KM, Herwald SE, Hogan JA, Pierce JV, Klipp E, Kumamoto CA. 2016. The game theory of Candida albicans colonization dynamics reveals host status-responsive gene expression. BMC Syst Biol. 10: 20.   books

Wildschutte JH*, Williams ZH*, Montesion M, Subramanian RP, Kidd JM, Coffin JM. 2016. Discovery of unfixed endogenous retrovirus insertions in diverse human populations. Proc Natl Acad Sci USA 113: E2326-E2334. (* equal contribution) books


Asrat S, Davis KM, Isberg RR. 2015. Modulation of the host innate immune and inflammatory response by translocated bacterial proteins. Cell Microbiol. 17: 785-795. books

Bhardwaj N, Montesion M, Roy F, Coffin JM. 2015. Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. Viruses 7: 939-968. books

Bou Ghanem EN, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN. 2015. The α-yocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J. Immunol. 194: 1090-1099. books

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. 2015. Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment. PLoS Pathog. 11: e1005126.  books

Burke HG, Heldwein EE 2015. Crystal structure of the human cytomegalovirus glycoprotein B. PLoS Pathog. 11: e1005227.  books

Fleming E, Lazinski DW, Camilli A. 2015. Carbon catabolite repression by seryl phosphorylated HPr is essential to Streptococcus pneumoniae in carbohydrate rich environments. Mol Microbiol. 6: e00078-15. books

Greene NG, Narciso AR, Filipe SR, Camilli A. 2015. Peptidoglycan branched stem peptides contribute to Streptococcus pneumoniae virulence by inhibiting pneumolysin release. PLoS Pathog. 11: e1004996. books

Hempstead AD, Isberg RR 2015. Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response. Proc Natl Acad Sci USA 112: E6790-E6797.   books

Jung SA, Chapman CA, Ng WL 2015. Quadruple quorum-sensing inputs control Vibrio cholerae virulence and maintain system robustness. PLoS Pathog. 11: e1004837. books

Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E. 2015. Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol. 194: 1763-1775. books

Klein BA, Chen T, Scott JC, Koenigsberg AL, Duncan MJ, Hu LT. 2015. Identification and characterization of a minisatellite contained within a novel miniature inverted-repeat transposable element (MITE) of Porphyromonas gingivalis Mob DNA 6:18.  books

Klein BA, Duncan MJ, Hu LT. 2015. Defining essential genes and identifying virulence factors of Porphyromonas gingivalis by massively parallel sequencing of transposon libraries (Tn-seq). Methods Mol Biol. 1279:25-43. books

Mitchell SL, Ismail AM, Kenrick SA, Camilli A. 2015. The VieB auxiliary protein negatively regulates the VieSA signal transduction system in Vibrio cholerae BMC Microbiol. 15: 59. books

Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. 2015. A single bacterial immune evasion strategy dismantles both MyD88 and TRIF signaling pathways downstream of TLR4. Cell Host Microbe 18: 682-693.   books


Asrat S, de Jesús DA, Hempstead AD, Ramabhadran V, Isberg RR. 2014. Bacterial pathogen manipulation of host membrane trafficking. Ann Rev Cell Dev Biol. 30: 79-109. books

Asrat S, Dugan AS, Isberg RR 2014. The frustrated host response to Legionella pneumophila Is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. PLoS Pathog. 10: e1004229. books

Baldwin M, Russo C, Li X, Chishti AH. 2014. Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis. Biochem Biophys Res Commun. 450: 1427-1432. books

Bhardwaj N, Maldarelli F, Mellors J, Coffin JM. 2014. HIV-1 infection leads to increased transcription of HERV-K (HML-2) proviruses in vivo but not to increased virion production. J Virol. 88: 11108-11120. books

Dalia AB, McDonough E, Camilli A. 2014. Multiplex genome editing by natural transformation. Proc Natl Acad Sci USA 111: 8937-8942. books

Henzy JE, Gifford RJ, Johnson WE, Coffin JM. 2014. A novel recombinant retrovirus in the genomes of modern birds combines features of avian and mammalian retroviruses. J Virol. 88: 2398-2405. books

Herwald SE, Kumamoto CA 2014. Candida albicans niche specialization: Features that distinguish biofilm cells from commensal cells. Curr Fungal Infect Rep. 8: 179-184. books

McDonough E, Lazinski DW, Camilli A. 2014. Identification of in vivo regulators of the Vibrio cholerae xds gene using a high-throughput genetic selection. Mol Microbiol. 42:302-315. books

Paczosa MK, Fisher ML, Maldonado-Arocho FJ, Mecsas J. 2014. Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection. Cell Microbiol. 16: 247-268. Abstract in PubMed

Pitts JD, Klabis J, Richards AL, Smith GA, Heldwein EE. 2014. Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking. J Virol. 88: 5462-5473. books

Seed KD, Yen M, Shapiro BJ, Hilaire IJ, Charles RC, Teng JE, Ivers LC, Boncy J, Harris JB, Camilli A. 2014. Evolutionary consequences of intra-patient phage predation on microbial populations. ELife 3:e03497. books

Wildschutte JH, Ram D, Subramanian R, Stevens VL, Coffin JM. 2014. The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls. Retrovirology 12: 62. books


Amyot WM, Dejesús D, Isberg RR. 2013. Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system. Infect Immun. 81: 3239-3252. books  (Correction Infect Immun. 82: 4436.)

Banerjee P, Dejesus R, Gjoerup O, Schaffhausen BS. 2013. Viral Interference with DNA Repair by Targeting of the Single-Stranded DNA Binding Protein RPA. PLoS Pathog. 9: e1003725. books

Davis TR, Zucchi PC, Kumamoto CA. 2013. Calmodulin binding to Dfi1p promotes invasiveness of Candida albicans. PLoS One 8: e76239. books

De Jesús DA, O'Connor TJ, Isberg RR. 2013. Analysis of Legionella infection using RNAi in Drosophila cells. Methods Mol Biol. 954: 251-264. books

Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW. 2013. IcmQ in the type 4b secretion system contains an NAD(+) binding domain. Structure 21: 1361-1373. books

Harmon DE, Murphy JL, Davis AJ, Mecsas J. 2013. A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yops, but retains the ability to trigger Yop secretion in response to host cell contact. J Bacteriol. 195:2244-2254. books

Hempstead AD, Isberg RR. 2013. Host signal transduction and protein kinases Implicated in Legionella infection. Curr Top Microbiol Immunol. 376: 249-269. books

Henzy JE, Coffin JM. 2013. Betaretroviral envelope subunits are noncovalently associated and restricted to the mammalian class. J Virol. 87: 1937-1946. books

Kamp HD, Patimalla-Dipali B, Lazinski DW, Wallace-Gadsden F, Camilli A. 2013. Gene fitness landscapes of Vibrio cholerae at important stages of its life cycle. PLoS Pathog. 9: e1003800. books

Maldonado-Arocho FJ, Green C, Fisher ML, Paczosa MK, Mecsas J. 2013. Adhesins and host serum factors drive Yop translocation by Yersinia into professional phagocytes during animal infection. PLoS Pathog. 9: e1003415. books

McDonough E, Bradley E, Camilli A. 2013. Regulating the Transition of Vibrio cholerae Out of the Host. In: Regulation of Bacterial Virulence. ML Vasil, AJ Darwin (ed) ASM Press, Washington, DC. 

Mittal M, Pechter KB, Picossi S, Kim HJ, Kerstein KO, Sonenshein AL. 2013. Dual role of CcpC protein in regulation of aconitase gene expression in Listeria monocytogenes and Bacillus subtilis. Microbiology 159 (Pt 1): 68-76. Abstract in PubMed

Pechter KB, Meyer FM, Serio AW, Stülke J, Sonenshein AL. 2013. Two roles for aconitase in the regulation of tricarboxylic acid branch gene expression in Bacillus subtilis. J Bacteriol. 195: 1525-1537. * equal contribution Abstract in PubMed

Pierce JV, Dignard D, Whiteway M, Kumamoto CA. 2013. Normal adaptation of Candida albicans to the murine GI tract requires Efg1p-dependent regulation of metabolic and host defense genes. Eukaryot Cell 12: 37-49. books

Rolan HG*, Durand EA*, Mecsas J. 2013. Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection. Cell Host & Microbe 14: 306-317. Abstract in PubMed

Scott JC, Klein BA, Duran-Pinedo A, Hu L, Duncan MJ. 2013. A two-component system regulates hemin acquisition in Porphyromonas gingivalis. PLoS One 8: e73351. books

Silverman JL, Heldwein EE. 2013. Mutations in the cytoplasmic tail of HSV-1 gH reduce the fusogenicity of gB in transfected cells. J Virol. 87: 10139-10147. books


Bensaci M, Bhattacharya D, Clark R, Hu LT.  2012. Oral vaccination with vaccinia virus expressing the tick antigen subolesin inhibits tick feeding and transmission of Borrelia burgdorferi. Vaccine 30: 6040-6046. books

Crimmins GT, Mohammadi S, Green ER, Bergman MA, Isberg RR, Mecsas J.  2012. Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. PLoS Pathog. 8: e1002828.  books

De Jesús DA, O'Connor TJ, Isberg RR. 2012. Analysis of Legionella Infection Using RNAi in Drosophila Cells. Methods Mol Biol. 954: 251-264. books

Klein BA, Tenorio EL, Lazinski DW, Camilli A, Duncan MJ, Hu LT. 2012. Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis. BMC Genomics 13: 578. books

Li X, Marinkovic M, Russo C, McKnight CJ, Coetzer TL, Chishti AH. 2012. Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells. Mol Biochem Parasitol. 183: 23-31. books 

Liu M, Haenssler E, Uehara T, Losick VP, Park JT, Isberg RR. 2012. The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity. Cell Host Microbe 12: 166-176. books

Meehan BM, Baughn AD, Gallegos R, Malamy MH. 2012. Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis.Proc Natl Acad Sci USA 109: 12153-12158 books

Meehan BM, Malamy MH. 2012.  Fumarate reductase is a major contributor to the generation of reactive oxygen species in the anaerobe Bacteroides fragilis. Microbiology. 158: 539-546. books

Pierce JV, Kumamoto CA. 2012. Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations. MBio 3: e00117-12. books

Price KE, Greene NG, Camilli A. 2012. Export requirements of pneumolysin in Streptococcus pneumoniae. J Bacteriol. 194: 3651-3660. books

Silverman JL, Greene NG, King DS, Heldwein EE. 2012. Membrane requirement for the folding of the HSV-1 gB cytodomain suggests a unique mechanism of fusion regulation. J Virol. 86: 8171-8184.  books

Tipper CH, Cingöz O, Coffin JM. 2012. Mus spicilegus endogenous retrovirus HEMV uses murine sodium-dependent myo-inositol transporter 1 as a receptor. J Virol. 86: 6341-6344. books

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development