Sharon Wu


Sharon Wu
BS, Molecular Biophysics & Biochemistry
Yale University
New Haven, Ct
MD, PhD Student
Karl Munger, PhD, Rotation Adviser




High-risk human papillomavirus (HPV) is the primary risk factor for cervical cancer. Expression of the viral oncoproteins E6 and E7 is required for maintaining malignant growth of cervical cancer cells. Prior work in the lab has shown that HPV16 E7 triggers epigenetic reprogramming of the host cell, specifically a decrease in the repressive trimethyl marks of H3K27 via induction of demethylases KDM6A and KDM6B. During my rotation, I examined the mechanisms leading to induction of KDM6A and 6B expression, focusing on replication stress. I also studied the interactions between HPV8 E6 and members of the Hippo pathway, a signaling pathway involved in regulating organ growth and cell proliferation.

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