Julia Hisey

julia

Julia Hisey
BS, Biology
Tufts University
Medford, MA
MD, PhD Student
Sergei Mirkin, PhD, Rotation Adviser

 

 

 

Repeat expansion diseases are often characterized by repeats that can form non-canonical DNA structures such as hairpins, quadruplexes, and triplexes. Friedreich’s Ataxia (FRDA) is a repeat expansion disease associated with GAA repeats in the first intron of the frataxin gene that can form a secondary DNA structure called H-DNA. Repetitive sequences like GAA that are able to form non-B DNA structures are frequently the site of cancer breakpoints and translocations. We are using yeast as a model system to characterize rearrangements at GAA repeats and determine the mechanism by which the rearrangements occur.

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