Julia Hisey


Julia Hisey
BS, Biology
Tufts University
Medford, MA
MD, PhD Student
Sergei Mirkin, PhD, Rotation Adviser




Repeat expansion diseases are often characterized by repeats that can form non-canonical DNA structures such as hairpins, quadruplexes, and triplexes. Friedreich’s Ataxia (FRDA) is a repeat expansion disease associated with GAA repeats in the first intron of the frataxin gene that can form a secondary DNA structure called H-DNA. Repetitive sequences like GAA that are able to form non-B DNA structures are frequently the site of cancer breakpoints and translocations. We are using yeast as a model system to characterize rearrangements at GAA repeats and determine the mechanism by which the rearrangements occur.

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