University of Southern California
Los Angeles, CA
MD, PhD Student
Iris Jaffe, MD, PhD, Rotation Adviser
Aging is characterized by a progressive loss of physiological integrity and homeostatic capacity associated with changes in gene expression mediated by epigenetic markers, such as post-translational histone modifications. Determining where these modifications occur, how they accumulate, and the genes affected are important studies to identify epigenetic drivers of disease. Previous work using mass spectrometry showed a down-regulation of H3K27 mono-methylation and tri-methylation with an up-regulation in H3K27 acetylation in mouse aortic smooth muscle cells with aging. My rotation project in the Jaffe lab investigates whether there is a similar trend across primary aortic smooth muscle cells from human donors with aging and whether there are sex-specific differences.