Jacob Klickstein


Jacob Klickstein
BS, Biology, Chemistry
Tufts University
Medford, MA
MD, PhD Student
Malavika Raman, PhD, Rotation Adviser




A hallmark of many neurodegenerative diseases such as ALS is protein aggregation, which interrupts normal cell function. Studying the protein degradation pathway can give us insights into what goes wrong in this pathway that causes the build-up of these pathogenic proteins. For my first summer research rotation, I have been working in the Raman lab creating cell lines that stably express mutant forms of TDP43, FUS, and SOD1: proteins that are found in ALS related aggregates. These cell lines will be a valuable tool to study the protein degradation pathway, specifically the role of VCP and it's adapter UBXN1.

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