BA, Biology, Neuroscience & Behavior
MD, PhD Student in Neuroscience
Giuseppina Tesco, MD, PhD, Adviser
Beta amyloid is the principal component of amyloid plaques, the pathological hallmark of Alzheimer’s disease. BACE1, the beta secretase, is integral in the formation of beta amyloid (Aβ) from amyloid precursor protein (APP). BACE1 is a primary target for therapies aimed to prevent or treat Alzheimer's disease. An alternative approach to BACE1 small-molecule inhibitors is the indirect inhibition of BACE1 through the modulation of regulatory mechanisms that control BACE1 levels or BACE1 trafficking to acidic compartments where it is optimally active. My thesis examined the role of ubiquitination in BACE1 degradation and identifying molecules in the ubiquitin machinery that can be targeted to increase BACE1 degradation.
I am now completing the third year of medical school