California Institute of Technology
MD, PhD Student
Bree Aldridge, PhD, Rotation Adviser
Tuberculosis infects a third of the world yet and treating the disease remains difficult due to a long antibiotic regimen. Although the antibiotics kill a significant portion of Mycobacterium tuberculosis, some subpopulations remain drug tolerant and are able to tolerate its stress. The Aldridge lab combines single-cell measurements and computational modeling to better understand and physiologically describe this drug-tolerant Mycobacterium subpopulation. My summer rotation project aims to understand Mycobacterium smegmatic growth properties and regulation under iron limitation conditions. Iron is an essential factor for Mycobacterium survival, and is known to play a role in infections.