Curie Ahn

curie

Curie Ahn
BS, Biology
California Institute of Technology
Pasadena, CA
MD, PhD Student
Karl Munger, PhD, Rotation Adviser

 

 

 

Human papilloma virus (HPV) is a cancer causing virus, that leads to cervical cancer which accounts for ~12% of human cancers. HPV has been known to target tumor suppressor proteins in the host, but new studies have suggested that DNA tumor viruses may also hijack the host cell’s immune response via interactions with stimulator of interferon genes (STING). There are two pathways in which a cell can sense the environment. One pathway is via sensing RNA, and the other by sensing DNA. In my research rotation, I am studying whether the expression of oncogenic E7 protein can lead to inhibition of cGAS-STING DNA-sensing pathway in Normal Oral Keratinocytes (NOK) and the immortalized Human Foreskin Keratinocytes (iHFK) cell lines.

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