Anthony Sheets


Anthony Sheets 
BA, Philosophy
Brown University 
Providence, RI 
MD, PhD Student in Cellular & Molecular Physiology
Ira Herman, PhD, Adviser




Vascular remodeling involves endothelial cell proliferation, differentiation and motility, features controlled by highly contractile pericytes. Their contractility is mediated by the Rho-GTPases, which control many aspects of intracellular actin dynamics. These cytoskeletal changes also thought to play a role in the dysregulation of vessel tone and hypertrophic remodeling observed in primary and secondary hypertension. To explore this hypothesis, I focused on whether cyclic deformation at hypertensive pressures altered pericyte cytoskeletal architecture.

I am now completing the fourth year of medical school.

Apply to the MSTP via AMCAS