MD, PhD Student in Cellular & Molecular Physiology
Ira Herman, PhD, Adviser
Vascular remodeling involves endothelial cell proliferation, differentiation and motility, features controlled by highly contractile pericytes. Their contractility is mediated by the Rho-GTPases, which control many aspects of intracellular actin dynamics. These cytoskeletal changes also thought to play a role in the dysregulation of vessel tone and hypertrophic remodeling observed in primary and secondary hypertension. To explore this hypothesis, I focused on whether cyclic deformation at hypertensive pressures altered pericyte cytoskeletal architecture.
I am now completing the third year of medical school.