Student Publications

2017


Bou Ghanem EN, Lee JN, Joma BH, Meydani SN, Leong JM, Panda A. 2017. The Alpha-tocopherol form of Vitamin E boosts elastase activity of human PMNs and their ability to kill Streptococcus pneumoniae. Front Cell Infect Microbiol. 7:161.  books

DeCicco RePass MA, Chen Y, Lin Y, Zhou W, Kaplan DL, Ward HD. 2017. A novel bioengineered 3D human intestinal model for long-term infection of Cryptosporidium parvum. Infect Immun. 85: pii: e00731-16. books

Larkin B, Ilyukha V, Sorokin M, Buzdin A, Vannier E, Poltorak A. 2017. Cutting Edge: Activation of STING in T cells induces Type I IFN responses and cell death. J Immunol. Epub ahead of print. books

Nevers T, Salvador AM, Velazquez F, Ngwenyama N, Carrillo-Salinas FJ, Aronovitz M, Blanton RM, Alcaide P. 2017. Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure. J Exp Med. Epub ahead of print. books

Nguyen GT, Green ER, Mecsas J. 2017. Neutrophils to the ROScue: Mechanisms of NADPH oxidase activation and bacterial resistance. Front Cell Infect Microbiol. 7:373. books

Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. 2017. Kinase activities of RIPK1 and RIPK3 can direct IFN-β synthesis induced by lipopolysaccharide. J Immunol. 198: 4435-3347.  books

Vong M, Ludington JG, Ward HD, Nibert ML. 2017. Complete cryspovirus genome sequences from Cryptosporidium parvum isolate Iowa. Arch Virol. Epub ahead of print. books

2016


Ludington JG, Ward HD. 2016. The Cryptosporidium parvum C-type lectin CpClec mediates infection of intestinal epithelial cells via interactions with sulfated proteoglycans. Infect Immun. 84: 1593-1602.  books

Paczosa MK, Mecsas J. 2016. Klebsiella pneumoniae: Going on the offense with a strong defense. Microbiol Mol Biol Rev. 80: 629-661.  books

Ram DR, Ilyukha V, Volkova T, Buzdin A, Tai A, Smirnova I, Poltorak A. 2016. Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proc Natl Acad Sci USA 113: 1606-1611.  books

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P. 2016. Intercellular adhesion molecule 1 regulates left ventricular leukocyte infiltration, cardiac remodeling, and function in pressure overload-induced heart failure. J Am Heart Assoc. pii: e003126.  books

Sampson JF, Suryawanshi A, Chen WS, Rabinovich GA, Panjwani N. 2016. Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling. Immunol Cell Biol. 94: 213-219.   books

Surpris G, Poltorak A. 2016. The expanding regulatory network of STING-mediated signaling.  Curr Opin Microbiol. 32: 144-150. books

Surpris G, Chan J, Thompson M, Ilyukha V, Liu BC, Atianand M, Sharma S, Volkova T, Smirnova I, Fitzgerald KA, Poltorak A. 2016. Cutting Edge: Novel Tmem173 allele reveals importance of STING N terminus in trafficking and type I IFN production. J Immunol. 196: 547-552. Abstract in PubMed

Thorley-Lawson D, Deitsch KW, Duca KA, Torgbor C. 2016. The link between Plasmodium falciparum malaria and dndemic Burkitt's Lymphoma-New insight into a 50-year-old enigma. PLoS Pathog. 12: e1005331.  books

Velázquez F, Grodecki-Pena A, Knapp A, Salvador AM, Nevers T, Croce KJ, Alcaide P. 2016. CD43 functions as an E-selectin ligand for Th17 cells in vitro and is required for rolling on the vascular endothelium and Th17 cell recruitment during inflammation in vivo. J Immunol. 196: 1305-1316.  books

2015


Ludington JG, Ward HD. 2015. Systemic and mucosal immune responses to Cryptosporidium-vaccine development. Curr Topics Med Rep. 2: 171-180.  books

McDonald G, Cabal N, Vannier A, Umiker B, Yin RH, Orjalo AV Jr, Johansson HE, Han JH, Imanishi-Kari T. 2015. Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked Toll-like receptor 8. Front Immunol. 6: 457. books

Nevers T, Salvador AM, Grodecki-Pena A, Knapp A, Velazquez F, Aronovitz M, Kapur NK, Karas RH, Blanton RM, Alcaide P. 2015. Left ventricular T cell recruitment contributes to the pathogenesis of heart failure. Circ Heat Fail. 8: 776-787.  books

Qiu J, Smith P, Leahy L, Thorley-Lawson DA. 2015. The Epstein-Barr virus encoded BART miRNAs potentiate tumor growth In vivo. PLoS Pathog. 11: e1004561. books

Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. 2015. A single bacterial immune evasion strategy dismantles both MyD88 and TRIF signaling pathways downstream of TLR4. Cell Host Microbe 18: 682-693.   books

Sampson JF, Hasegawa E, Mulki L, Suryawanshi A, Jiang S, Chen WS, Rabinovich GA, Connor KM, Panjwani N. 2015. Galectin-8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response. PLoS One 10: e130772.  books

Smith PM, Sproule TJ, Philip VM, Roopenian DC, Stadecker MJ. 2015. Minor genomic differences between related B6 and B10 mice affect severity of schistosome infection by governing the mode of dendritic cell activation. Eur J Immunol. 45: 2312-2323. Abstract in PubMed

Suryawanshi A, Cao Z, Sampson JF, Panjwani N. 2015. IL-17A-mediated protection against Acanthamoeba keratitis. J Immunol. 194: 650-663. books

2014


Fray MA, Bunnell SC. 2014. p53 Keeps Bystanders at the Gates. Immunity 40: 633-635. Abstract in PubMed

Han JH, Umiker BR, Kazimirova AA, Fray M, Korgaonkar P, Selsing E, Imanishi-Kari T. 2014. Expression of an anti-RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN-I expression. Eur J Immunol. 44: 215-226. books

Krause DS, Lazarides K, Lewis JB, von Andrian UH, Van Etten RA. 2014. Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche. Blood 123: 1361-1371. books

Paczosa MK, Fisher ML, Maldonado-Arocho FJ, Mecsas J. 2014. Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection. Cell Microbiol. 16: 247-268. Abstract in PubMed

Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM, Russo JM, Salantes DB, Lai CQ, Parnell LD, Yun TJ, Cheong C, Bunnell SC, Hacohen N, Stadecker MJ. 2014. CD209a expression on dendritic cells Is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. J Immunol. 192: 4655-4665. Abstract in PubMed

Ponichtera HE, Stadecker MJ. 2014. Dendritic cell expression of the c-type lectin receptor CD209a: a novel innate parasite-sensing mechanism inducing Th17 cells that drive severe immunopathology in murine schistosome infection. Exp Parasitol. 192: 4655-4665. Abstract in PubMed

Qiu J, Thorley-Lawson DA. EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells. Proc Natl Acad Sci USA 111: 11157-11162. books

Salvador R, Aridgides D, PereiraPerrin M. 2014. Parasite-derived neurotrophic factor/trans-sialidase of Trypanosoma cruzi links neurotrophic signaling to cardiac innate immune response. Infect Immun. 82: 3687-3696. books

Schworer SA, Smirnova II, Kurbatova I, Bagina U, Churova M, Fowler T, Roy AL, Degterev A, Poltorak A. 2014. Toll-like receptor-mediated downregulation of the deubiquitinase CYLD protects macrophages from necroptosis in wild-derived mice. J Biol Chem. 289: 14422-14433. books

Torgbor C, Awuah P, Deitsch K, Kalantari P, Duca KA, Thorley-Lawson DA. 2014. A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis. PLoS Pathog. 10: e1004170. books

Umiker BR*, Andersson S*, Fernandez L, Korgaokar P, Larbi A, Pilichowska M, Weinkauf CC, Wortis HH, Kearney JF, Imanishi-Kari T. 2014. Dosage of X-linked toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus. Eur J Immunol. 44: 1503-1516. (*equal contribution) books

Umiker BR, McDonald G, Larbi A, Medina CO, Reth M, Imanishi-Kari T. 2014. Production of IgG autoantibody requires expression of activation-induced deaminase in early developing B cells in a mouse model of SLE. Eur J Immunol. 44: 3093-3108. books

Wildschutte JH, Ram D, Subramanian R, Stevens VL, Coffin JM. 2014. The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls. Retrovirology 11: 62. books

2013


Aridgides D, Salvador R, Pereiraperrin M. 2013. Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve Growth Factor Receptor TrkA. PLoS One 8: e57450. books

Aridgides D, Salvador R, Pereiraperrin M. 2013. Trypanosoma cruzi highjacks TrkC to enter cardiomyocytes and cardiac fibroblasts while exploiting TrkA for cardioprotection against oxidative stress. Cell Microbiol. 15: 1357-1366. books

Bhalchandra S, Ludington J, Coppens I, Ward HD. 2013. Identification and characterization of CpClec, a novel C-type lectin domain-containing mucin-like glycoprotein of Cryptosporidium. Infect Immun. 81: 3356-3365. books

Bhat N, Wojczyk BS, DeCicco M, Castrodad C, Spitalnik S, Ward H. 2013. Identification of a family of four UDP-polypeptide N-acetylgalactosaminyl transferases in Cryptosporidium species. Mol Biochem Parasitol. 191: 24-27. books

Hang L, Blum AM, Setiawan T, Urban JP Jr, Stoyanoff KM, Weinstock JV. 2013. Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+ T cells enhancing their capacity to prevent colitis. J Immunol. 191: 1927-1934. books

Maldonado-Arocho FJ, Green C, Fisher ML, Paczosa MK, Mecsas J. 2013. Adhesins and host serum factors drive Yop translocation by Yersinia into professional phagocytes during animal infection. PLoS Pathog. 9: e1003415. books

Moseman AP, Moseman EA, Schworer S, Smirnova I, Volkova T, von Andrian U, Poltorak A. 2013. Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. J Immunol. 191: 5615-5624. books

Ophir MJ, Liu BC, Bunnell SC. 2013. The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms. J Cell Biol. 203: 1021-1041. books

Petnicki-Ocwieja T, Chung E, Acosta DI, Ramos LT, Shin OS, Ghosh S, Kobzik L, Li X, Hu LT. 2013. TRIF mediates TLR2 dependent inflammatory responses to Borrelia burgdorferi. Infect Immun. 81:402-410. books

Thorley-Lawson DA, Hawkins JB, Tracy SI, Shapiro M. 2013. The pathogenesis of Epstein-Barr virus persistent infection. Curr Opin Virol. 3: 227-232. books

2012


Balter BB, Ciccone DN, Oettinger MA, Selsing E. 2012. Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations. J Immunol. 52: 1-8. books

Blum AM, Hang L, Setiawan T, Urban JP Jr, Stoyanoff KM, Leung J, Weinstock JV. 2012. Heligmosomoides polygyrus bakeri induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut T cell responses. J Immunol. 189: 2512-2520. books

Larkin BM, Smith PM, Ponichtera HE, Shainheit MG, Rutitzky LI, Stadecker MJ. 2012. Induction and regulation of pathogenic Th17 cell responses in schistosomiasis. Semin Immunopathol. 34: 873-888. books

Leung J, Hang L, Blum A, Setiawan T, Stoyanoff K, Weinstock J. 2012. Heligmosomoides polygyrus abrogates antigen-specific gut injury in a murine model of inflammatory bowel disease. Inflamm Bowel Dis. 18: 1447-1455. books

Lu, YF, Gavrilescu LC, Betancur M, Lazarides K, Klingemann H, Van Etten RA. 2012. Distinct graft-vs-leukemic stem cell effects of early or delayed donor leukocyte infusions in a mouse chronic myeloid leukemia model. Blood 119: 273-284. books

Smith PA, Merritt D, Barr L, Thorley-Lawson DA. 2012. An orthotopic model of metastatic nasopharyngeal carcinoma and its application in elucidating a therapeutic target that inhibits metastasis. Genes Cancer. 2: 1023-1033. books

Tracy SI, Kakalacheva K, Lünemann JD, Luzuriaga K, Middeldorp J, Thorley-Lawson DA. 2012. Persistence of Epstein-Barr virus in self-reactive memory B cells. J Virol. 86: 12330-12340. books

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research