Sneha Borikar


Sneha Borikar
BS, Bioengineering - Biotechnology
University of California - San Diego
San Diego, CA
PhD Student in Genetics - JAX Track
Jennifer Trowbridge, PhD, Adviser




Hematopoietic stem cells (HSCs) are a rare population of cells that are responsible for life-long generation of all lineages of blood cells. HSCs must establish a balance between opposing cell fates: self-renewal (cell division resulting in at least one HSC) and initiation of hematopoietic differentiation. It is becoming increasingly clear that epigenetic regulation is an important component dictating HSC fate decisions. In addition, multiple signaling pathways have been implicated in the regulation of HSC cell fate. However, how specific signaling pathways and epigenetic modifications integrate to control cell fate is unknown. In particular, my project focuses on better understanding how Wnt signaling and epigenetic modifications interact to dictate cell fate.  This knowledge can be used to improve success of bone marrow transplants and increase the robustness of new engraftment therapies for blood disorders.

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research