Kate Foley


Kate Foley
BS, Biology
Binghamton University
Binghamton, NY
PhD Student in Genetics - JAX Track
Gareth Howell, PhD, Adviser





Our lab focuses on the early markers for Alzheimer’s disease and how various genetic and environmental risk factors influence early progression in mouse models. Aging is the greatest risk factor for late onset Alzheimer’s disease (LOAD); so investigating the genetic changes that occur with age in key cell types (astrocytes) is critical. APOE4, an allelic variant of the APOE gene, is the largest genetic risk factor for LOAD. There are three genetic variants of the APOE gene that have differing levels of risk or protection to LOAD. I would like to better understand how these gene variants function, within the astrocyte cells of the brain, to alter the risk for LOAD. Additionally, many studies have discovered that environmental factors, such as diet and exercise, also alter the risk for Alzheimer’s disease. My project will tease apart how diet and exercise affect age and genetic contributions (APOE) to help distinguish an underlying mechanism to each risk.

Back to the Howell Profile Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research