Alex Stanton

Alex

Alex Stanton
BS, Cell Biology
University of California - Davis
Davis, CA
MS, Biology
California State University - Chico
Chico, CA
PhD Student in Genetics - JAX Track
Steven Munger, PhD, Adviser

 

 

My research stems from our recent observation that proteins which interact in multi-protein partnerships or complexes are tightly co-expressed, with the steady state abundance of each member protein set at the abundance of the lowest expressed protein constituent. This post-transcriptional mechanism, which we term "Stoichiometric Buffering" likely stems from increased stability conferred by protein-protein interactions. My project seeks to elucidate the molecular details underlying this post-translational regulatory mechanism. Previous work by the Munger lab and collaborating labs has gathered expression and protein quantitative trait loci (eQTL & pQTL, respectively) data from Diversity Outbred (DO) mouse liver and kidney. Using these data, we predicted for stoichiometrically buffered protein complexes by screening for proteins whose abundance does not correlate to their own mRNA expression, but rather to the abundance of another protein. Currently, I am validating one pair of candidates (NNT and TMEM68), developing a pipeline for further validations, and using polysome profiling of DO founder strain livers to improve our predictions by introducing a measure of translation on top of steady state protein levels.

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research