Alex Fine

Alex

Alexander Fine
BS, Biochemistry & Molecular Biology
University of Massachusetts - Amherst
Amherst, MA
PhD Student in Genetics - JAX Track
Gregory Carter, PhD, Adviser

 

 

 

 

Homologous recombination is a necessary step in meiosis, and therefore essential for successful gametogenesis. Homologous recombination occurs during prophase of meiosis I after programmed double-strand breaks (DSB) in DNA. The zinc finger protein PRDM9 is the primary known selector of genomic loci for DSBs in the early substages of prophase I; however, its targeting mechanism and the role of its epigenetic modifications throughout prophase I are not fully understood. As a part of the Carter lab, I am working in collaboration with the Handel and the Paigen/Petko groups at the Jackson Labs to examine the role of PRDM9 in spermatogenesis. Our goal is to develop an integrative genomic model of germline development throughout the meiotic stages.

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