Student Publications


Freytsis M, Baugh L, Liu Z, Georgakoudi I, Hinds PW, Black LD, Huggins GS. 2018. Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation. PLoS One 13: e0190623. books

Khanna P, Maron JL, Walt DR. 2017. Development of a rapid salivary proteomic platform for oral feeding readiness in the preterm newborn. Front Pediatr. 5: 268. books

Neil AJ, Liang MU, Khristich AN, Shah KA, Mirkin SM. 2018. RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication. Nucleic Acids Res. Epub ahead of print. books

Sweeney MF, Sonnenschein C, Soto AM. 2018. Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D. Cancer Cell Int. 18: 43. books


Benway CJ, Iacomini J. 2017. Defining a microRNA-mRNA interaction map for calcineurin inhibitor induced nephrotoxicity. Am J Transplant. Epub ahead of print. books

Khanna P, Maron JL, Walt DR. 2017. Development of a rapid salivary proteomic platform for oral feeding readiness in the preterm newborn. Front Pediatr. 5: 268. books

Kulkarni S, Goel S, Sengupta S, Cochran BH. 2017. A large-scale RNAi screen identifies SGK1 as a key survival kinase for GBM stem cells. Mol Cancer Res. Epub ahead of print. Abstract in PubMed

McDonald G, Medina CO, Pilichowska M, Kearney JF, Shinkura R, Selsing E, Wortis HH, Honjo T, Imanishi-Kari T. 2017. Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genes. Front Immunol. 8: 1094. books

McGinty RJ, Rubinstein RG, Neil AJ, Dominska M, Kiktev D, Petes TD, Mirkin SM. 2017. Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair. Genome Res. Epub ahead of print. books

Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM. 2017. Mechanisms of HERV-K (HML-2) transcription during human mammary epithelial cell transformation. J Virol. Epub ahead of print.  books

Neil AJ, Kim JC, Mirkin SM. 2017. Precarious maintenance of simple DNA repeats in eukaryotes. Bioessasy Epub ahead of print. books

Radchenko EA, McGinty RJ, Aksenova AY, Neil AJ, Mirkin SM 2017. Quantitative Analysis of the Rates for Repeat-Mediated Genome Instability in a Yeast Experimental System. Methods Mol Biol. 1672: 421-428. books

Tsutakawa SE, Thompson MJ, Arvai AS, Neil AJ, Shaw SJ, Algasaier SI, Kim JC, Finger LD, Jardine E, Gotham VJB, Sarker AH, Her MZ, Rashid F, Hamdan SM, Mirkin SM, Grasby JA, Tainer JA. 2017. Nat Comm. 8: 15855. books


Graham LC, Harder JM, Soto I, de Vries WN, John SW, Howell GR. 2016. Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease. Sci Rep. 6: 21568. books

Gross K, Wronski A, Skibinski A, Phillips S, Kuperwasser C. 2016. Cell fate decisions during breast cancer development. J Dev Biol. 4: 4.   books

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe. 21: 169-181. books

Leaderer D, Cashman SM, Kumar-Singh R. 2016. G-quartet oligonucleotide mediated delivery of proteins into photoreceptors and retinal pigment epithelium via intravitreal injection. Exp Eye Res. 145: 380-392.   Abstract in PubMed

Papageorgiou I, Freytsis M, Court MH. 2016. Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Biochem Pharmacol. 117: 78-87. books

Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. 2016. Targeting liver fibrosis with a cell-penetrating PAR2 pepducin. J Biol Chem. 291: 23188-23198. books

Speroni L, Sweeney MF, Sonnenschein C, Soto AM. 2016. A hormone-responsive 3D culture model of the human mammary gland epithelium. J Vis Exp. (108): e53098. books

Soto I, Grabowska WA, Onos KD, Graham LC, Jackson HM, Simeone SN, Howell GR. 2016. Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease. Neurobiol Aging 42: 50-60. books

Sweeney MF, Hasan N, Soto AM, Sonnenschein C. 2015. Environmental endocrine disruptors: Effects on the human male reproductive system. Rev Endocr Metab Disord. 16: 341-357. books

Weindel CG, Richey LJ, Mehta AJ, Shah M, Huber BT. 2016. Autophagy in dendritic cells and B cells is critical for the inflammatory state of TLR7-mediated autoimmunity. J Immunol. 198: 1081-1092.  books

Wildschutte JH*, Williams ZH*, Montesion M, Subramanian RP, Kidd JM, Coffin JM. 2016. Discovery of unfixed endogenous retrovirus insertions in diverse human populations. Proc Natl Acad Sci USA 113: E2326-E2334. (* equal contribution) books


Bhardwaj N, Montesion M, Roy F, Coffin JM. 2015. Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. Viruses 7: 939-968. books

Gilbert MA, Lin B, Peterson J, Jang W, Schwob JE. 2015. Neuregulin1 and ErbB expression in the uninjured and regenerating olfactory mucosa. Gene Exp Patterns 19: 108-119. books

Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW. 2015. The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A. 167: 1993-2008. books

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. 2015. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 212: 287-295. books

Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR. 2015. DBA/2J Genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. PLoS One 10: e0125897. books

Jain S, Chen J, Nicolae A, Wang H, Shin DM, Adkins EB, Sproule TJ, Leeth CM, Sakai T, Kovalchuk AL, Raffeld M, Ward JM, Rehg JE, Waldmann TA, Jaffe ES, Roopenian DC, Morse HC 3rd. 2015. Am J Pathol. 185: 3102-3114. Abstract in PubMed

Khanna P, Walt DR. 2015. Salivary diagnostics using a portable point-of-service platform: A review. Clin Ther. 37: 498-504. books

Leaderer D, Cashman SM, Kumar-Singh R. 2015. Adeno-associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59. J Gene Med. 17: 101-115. Abstract in PubMed

Leaderer D, Cashman SM, Kumar-Singh R. 2015. Topical application of a G-quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration. Exp Eye Res. 140: 171-178.   Abstract in PubMed

Luo C, Pietruska JR, Sheng J, Bronson RT, Hu MG, Cui R, Hinds PW. 2015. Expression of oncogenic BRAFV 600E in melanocytes induces Schwannian differentiation in vivo. Pigment Cell Melanoma Res. 28: 603-606.  books

Mazumdar S, Arendt LM, Phillips S, Sedic M, Kuperwasser C, Gill G. 2015. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS One 10: e0121281. books

McDonald G, Cabal N, Vannier A, Umiker B, Yin RH, Orjalo AV Jr, Johansson HE, Han JH, Imanishi-Kari T. 2015. Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked Toll-like receptor 8. Front Immunol. 6: 457. books

Soto I, Graham LC, Richter HJ, Simeone SN, Radell JE, Grabowska W, Funkhouser WK, Howell MC, Howell GR. 2015. APOE stabilization by exercise prevents aging neurovascular dysfunction and complement induction. PLoS Biol. 13: e1002279. books

Sun X, Pinacho R, Saia G, Punko D, Meana JJ, Ramos B, Gill G. 2015. Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning. Dev Neurobiol. 75: 93-108. books

Weindel CG, Richey LJ, Bolland S, Mehta AJ, Kearney JF, Huber BT. 2015. B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy 11: 1010-1024.  books

Yuan J, Benway CJ, Bagley J, Iacomini J. 2015. MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN. Am J Transplant. 15: 1682-1691. books


Doyle JR, Harwood BN, Krishnaji ST, Krishnamurthy VM, Lin WE, Fortin JP, Kumar K, Kopin AS. 2014. A two-step strategy to enhance activity of low potency peptides. PLoS One 9: e110502. books

Foley CJ, Kuliopulos A. 2014. Mouse matrix metalloprotease-1a (Mmp1a) gives new insight Into MMP function. J Cell Physiol. 229: 1875-1880. books

Foley CJ, Fanjul-Fernández M, Bohm A, Nguyen N, Agarwal A, Austin K, Koukos G, Covic L, López-Otín C, Kuliopulos A. 2014. Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. Oncogene 33: 2264-2272. books

Harwood BN, Draper I, Kopin AS. 2014. Targeted inactivation of the rickets receptor in muscle compromises Drosophila viability. Exp Cell Biol. 271: 4091-4098. books

Lane JM, Doyle JR, Fortin JP, Kopin AS, Ordovás JM. 2014. Development of an OP9 derived cell Line as a robust model to rapidly study adipocyte differentiation. PLoS One 9: e112123. books

Phillips S, Kuperwasser C. 2014. SLUG: Critical regulator of epithelial cell identity in breast development and cancer. Cell Adh Migr. 8: 578-587. books

Phillips S, Prat A, Sedic M, Proia T, Wronski A, Mazumdar S, Skibinski A, Shirley SH, Perou CM, Gill G, Gupta PB, Kuperwasser C. 2014. Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation. Stem Cell Reports 2: 633-647. books

Saia G, Lalonde J, Sun X, Ramos B, Gill G. 2014. Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling. J Neurochem. 129: 743-752. books

Sheng J, Luo C, Jiang Y, Hinds PW, Xu Z, Hu GF. 2014. Transcription of angiogenin and ribonuclease 4 is regulated by RNA Polymerase III elements and a CCCTC-binding factor (CTCF)-dependent intragenic chromatin loop. J Biol Chem. 289: 12520-12534. books

Sproule TJ, Bubier JA, Grandi FC, Sun VZ, Philip VM, McPhee CG, Adkins EB, Sundberg JP, Roopenian DC. 2014. Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice. PLoS Genet. 10: e1004068. books

Umiker BR*, Andersson S*, Fernandez L, Korgaokar P, Larbi A, Pilichowska M, Weinkauf CC, Wortis HH, Kearney JF, Imanishi-Kari T. 2014. Dosage of X-linked toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus. Eur J Immunol. 44: 1503-1516. (*equal contribution) books

Umiker BR, McDonald G, Larbi A, Medina CO, Reth M, Imanishi-Kari T. 2014. Production of IgG autoantibody requires expression of activation-induced deaminase in early developing B cells in a mouse model of SLE. Eur J Immunol. 44: 3093-3010. books


Arya MA, Tai AK, Wooten EC, Parkin CD, Kudryavtseva E, Huggins GS. 2013. Notch pathway activation contributes to inhibition of C2C12 myoblast differentiation by ethanol. Plos ONE 8: e71632 . books

Austin KM, Covic L, Kuliopulos A. 2013. Matrix metalloproteases and PAR1 activation. Blood 121: 431-439. books

Austin KM, Nguyen N, Javid G, Covic L, Kuliopulos A. 2013. Non-canonical MMP1-PAR1 signaling triggers vascular smooth muscle cell de-differentiation and arterial stenosis. J Biol Chem. 288: 23105-23115. books

Binder C, Cashman SM, Kumar-Singh R. 2013. Extended duration of transgene expression from pegylated POD nanoparticles enables attenuation of photoreceptor degeneration. PLoS One 8: e82295. Abstract in PubMed

Court MH, Freytsis M, Wang X, Peter I, Guillemette C, Hazarika S, Duan SX, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group. 2013.The UDP-Glucuronosyltransferase (UGT) 1A polymorphism c.2042C.G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A Exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failures. J Pharmacol Exp Ther. 345: 297-307. Abstract in PubMed

Delviks-Frankenberry K, Paprotka T, Cingöz O, Wildt S, Hu WS, Coffin JM, Pathak VK. 2013. Generation of multiple replication competent retroviruses through recombination between PreXMRV-1 and PreXMRV-2. J Virol. 87: 11525-11537. books

Graber JH, Nazeer FI, Yeh PC, Kuehner JN, Borikar S, Hoskinson D, Moore CL. 2013. DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast. Genome Res. 23: 1690-1703. books

Greenwald DL, Cashman SM, Kumar-Singh R. 2013. Mutation-independent rescue of a novel mouse model of Retinitis Pigmentosa. Gene Ther. 20: 425-434. books

Harwood BN, Fortin JP, Gao K, Chen C, Beinborn M, Kopin AS. 2013. Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila GPCR rickets. Mol Pharmacol. 83: 814-821. books

Howell GR, Soto I, Ryan M, Graham LC, Smith RS, John SW. 2013. Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice. J Neuroinflamm. 10: 76. books

Jackson HM, Soto I, Graham LC, Carter GW, Howell GR. 2013. Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease. BMC Genomics 14: 831. books

Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW. 2013. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res. 73: 4337-4338. books


Cingöz O, Paprotka T, Delviks-Frankenberry KA, Wildt S, Hu WS, Pathak VK, Coffin JM. 2012. Characterization, mapping and distribution of the two XMRV parental proviruses. J Virol. 86: 328-338. books

Cusano NE, Kiel DP, Demissie S, Karasik D, Adrienne Cupples L, Corella D, Gao Q, Richardson K, Yiannakouris N, Ordovas JM. 2012. A polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study. Calcif Tissue Int. 90: 96-107. books

Delviks-Frankenberry K, Cingöz O, Coffin JM, Pathak VK. 2012. Recombinant origin, contamination, and de-discovery of XMRV. Curr Opin Virol. 2: 499-507. books

Foley CJ, Luo C, O’Callaghan K, Hinds P, Covic L, Kuliopulos A. 2012. Matrix metalloprotease-1a promotes tumorigenesis and metastasis. J Biol Chem. 287: 24330-24338.  books

Gündüz V, Kong E, Bryan CD, Hinds PW. 2012. Loss of the retinoblastoma tumor suppressor protein in murine calvaria facilitates immortalization of osteoblast-adipocyte bipotent progenitor cells characterized by low expression of N cadherin. Mol Cell Biol. 32: 2561-2569. books

Petrovska I, Kumamoto CA. 2012 Functional importance of the DNA binding activity of Candida albicans Czf1p. PLoS One 7: e39624. books

Pritchard S, Peter I, Johnson KL, Bianchi DW. 2012. The natural history of fetal cells in postpartum murine maternal lung and bone marrow: a two-stage phenomenon. Chimerism 3: 59-64. books

Pritchard S, Bianchi DW. 2012. Fetal cell microchimerism in the maternal heart: baby gives back. Circ Res. 110: 3-5. books

Pritchard S, Wick HC, Slonim DK, Johnson KL, Bianchi DW. 2012. Comprehensive analysis of genes expressed by rare microchimeric fetal cells in the maternal mouse lung. Bio Reprod. 87: 42. books

Sims HI, Pham CD, Schnitzler GR. 2012. Mapping assembly favored and remodeled nucleosome positions on polynucleosomal templates. Methods Mol Bio. 833: 311-336. Abstract in PubMed

Tipper CH, Cingöz O, Coffin JM. 2012. Mus spicilegus endogenous retrovirus HEMV uses murine sodium-dependent myo-inositol transporter 1 as a receptor. J Virol. 86: 6341-6344.  books

Zhang W, Vazquez B, Andreeva V, Spear D, Kong E, Hinds PW, Yelick PC. 2012. Discrete phosphorylated retinoblastoma protein isoform expression in mouse tooth development. J Mol Histol. 43: 281-288. books

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development