Developmental and Regenerative Biology

Student working at the hood

Vision for Training


CMDB graduates with a research specialization in developmental and regenerative biology will have a strong foundation in the many areas of pathobiology in which “disease recapitulates development”. Faculty in Developmental and Regenerative Biology (DRB) directly link fundamental mechanisms of development—including stem and progenitor cell biology—to pathologic conditions such as cardiovascular disease, neurologic disease, inflammatory disease, aging, and tumorigenesis. A wide array of experimental approaches are used: biochemistry, cell and molecular biology, tissue engineering, and model systems such as Zebrafish, Drosophila, and C. elegans. Students specializing in DRB will be well equipped to help develop the next generation of precision-medicine tools.


Faculty with Active Research Programs


Please note that faculty designated as MMCRI are based in Scarborough, ME. Thesis research under the mentorship of these faculty is conducted at Maine Medical Center Research Institute in Scarborough, ME.

Thomas Biederer, PhD - Molecular mechanisms of synapse formation Send an e-mail  PI Profile

Lauren Black, III, PhD - Cardiovascular tissue engineering Send an e-mail  PI Profile

Peter Brooks, PhD (MMCRI) - Extracellular matrix and inflammation; angiogenesis and tumor progression Send an e-mail  PI Profile

Jake Jinkun Chen, DDS, PhD - Cell and molecular biology of bone Send an e-mail  PI Profile 

Chris Dulla, PhD - Spatiotemporal control of neurotransmitter transients Send an e-mail  PI Profile

Larry Feig, PhD - Ras and Ral GTPase signaling in learning and memory  Send an e-mail  PI Profile

Robert Friesel, PhD (MMCRI) - Angiogenesis, tissue remodeling and development Send an e-mail  PI Profile

Jonas Galper, MD, PhD - Sterol regulation of cardiovascular disease Send an e-mail  PI Profile

Thomas Gridley, PhD - Notch signaling in development and disease Send an e-mail 

Victor Hatini, PhD - Genetic approaches to patterning and organ development Send an e-mail  PI Profile

Ira Herman, PhD - Mechanics of motility, angiogenesis and wound healing: Therapeutics for regenerative medicine Send an e-mail  PI Profile

Gordon Huggins, MD - Molecular genetic mechanisms of cardiovascular development and disease Send an e-mail  PI Profile

Michele Jacob, PhD - Molecular mechanisms dirrecting synapse assembly and plasticity Send an e-mail  PI Profile

Iris Jaffe, MD, PhD - Aldosterone and the mineralocorticoid receptor in vascular function and disease Send an e-mail  PI Profile

Peter Juo, PhD - Localization and regulation of synaptic proteins Send an e-mail  PI Profile

David Kaplan, PhD - Tissue engineering and stem cells Send an e-mail  PI Profile

Dong Kong, PhD -  Synaptic plasticity and circuitry in neuron-metabolism  Send an e-mail  PI Profile

James Kubilus, PhD - Signaling in cornea development  Send an e-mail  PI Profile

Rajendra Kumar-Singh, PhD - Gene therapy for inherited retinal disorders Send an e-mail  PI Profile

Charlotte Kuperwasser, PhD - Molecular mechanisms of breast cancer and breast development Send an e-mail  PI Profile  

Lucy Liaw, PhD (MMCRI) -Blood vessel development and repair Send an e-mail  PI Profile

Volkhard Lindner, MD, PhD (MMCRI) - Genes associated with vascular injury and repair Send an e-mail  PI Profile

Leif Oxburgh, DVM, PhD (MMCRI) - BMP and regulation of kidney development Send an e-mail  PI Profile

Ilka Pinz, PhD (MMCRI) - Lipotoxicity and heart disease Send an e-mail  PI Profile

Igor Prudovsky, PhD (MMCRI) - Molecular events associated with protein release Send an e-mail  PI Profile

Maribel Rios, PhD - Obesity and mood disorders; neurodegeneration Send an e-mail  PI Profile

James Schwob, MD, PhD - Olfactory system development and regeneration Send an e-mail PI Profile

Allen Taylor, PhD - Aging and protein quality control, specifically in age-related eye disease and diet  Send an e-mail  PI Profile

Calvin Vary, PhD (MMCRI) -TGFβ in vascular development and disease Send an e-mail  PI Profile

Don Wojchowski, PhD (MMCRI) - Regulation of erythropoiesis and anemia development Send an e-mail  PI Profile

Pamela Yelick, PhD - Genetic analysis of craniofacial and tooth development Send an e-mail   PI Profile

Yongjie Yang, PhD - Astrocyte function and neurological disorders Send an e-mail  PI Profile

Li Zeng, PhD - Cartilage development and regeneration Send an e-mail  PI Profile


Faculty Participating in Teaching


John Castellot, PhD, Concentration Leader - Mechanisms of smooth muscle proliferation Send an e-mail  PI Profile

Daniel Cox, PhD - Molecular mechanisms of BKCa channel function  Send an e-mail  PI Profile

Christiane Dammann, MD - Fetal lung development Send an e-mail  PI Profile

Al-Walid El-Bermani, PhD - Mechanisms involved in innervation of the lung Send an e-mail  PI Profile

Eric Frank, PhD - Molecular mechanisms mediating synaptic connections between neurons Send an e-mail  PI Profile

Alvar Gustafson, PhD - Male reproductive physiology Send an e-mail  PI Profile

Douglas Jefferson, PhD - CF and ADPKD-associated hepatobiliary disease Send an e-mail   PI Profile

Janis Lem, PhD - Retinal degeneration mechanisms and phototransduction Send an e-mail  PI Profile

Thomas Linsenmayer, PhD - Corneal development and innervation; oxidative damage protective mechanisms Send an e-mail  PI Profile

Laura Liscum, PhD - Intracellular cholesterol transport and metabolism Send an e-mail  PI Profile

Jeffrey Marchant, PhD - Tissue engineering and cornea replacement Send an e-mail PI Profile

Karina Meiri, PhD - Regulation of neurogenesis and neuronal plasticity  Send an e-mail  PI Profile

Heber Nielsen, MD - Normal and abnormal regulation of fetal lung development Send an e-mail  PI Profile

Beverly Rubin, PhD - Effects of perinatal xenoestrogen on body weight and fetal development Send an e-mail  PI Profile

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research