Kathleen Nevola


Kathleen Nevola
BS, Chemical Biology
MS, Chemical Biology
Stevens Institute of Technology
Hoboken, NJ
PhD Student in Cell, Molecular & Developmental Biology
Christine Duarte, PhD, Adviser




Risperidone is an atypical antipsychotic (AA) drug that is used to treat schizophrenia and bipolar disorder as well as complications of dementia in older adults. Previous research has shown an association between AA treatment and fractures and falls in clinical studies, and mouse studies have shown that risperidone treatment induces bone loss. Interestingly, co-therapy with the beta-blocker propranolol significantly curtailed bone loss, suggesting bone loss is due to metabolic consequences of sympathetic nervous system activation. My research goal is to develop a mechanistic understanding of this process by collecting and analyzing multi-omics data including mRNA, proteomic, and lipidomic data to investigate the mechanism through which sympathetic activation leads to bone loss in risperidone-treated mice. Furthermore, I am developing a robust pipeline and new methods for integration of multi-omic data sources that may be applied to other datasets.

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