Nicole Sjoblom


Nicole Sjoblom
BS, Biochemistry
Stonehill College
Easton, MA
Biochemistry PhD Student
Rebecca Scheck, PhD, Adviser





My current work focuses on the protein TRIM21, also known as Ro52, whose role in innate immunity and autoimmune disease is not fully understood. TRIM21 has been found to be both a cytosolic Fc receptor and potent self-antigen that is especially relevant to diseases like systemic lupus erythematosus and Sjögren’s syndrome. My research looks to further understand TRIM21 and its antibody interactions. Specifically, we are investigating the proposal that TRIM21 generates bridged autoantibody complexes that may correlate with the progression of autoimmune diseases. We aim to develop tools that can be used to further evaluate these interactions in vitro and in vivo. If successful, my research will provide insight into the generation of novel therapeutics for the treatment of autoimmune diseases.

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February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

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