Nicole Sjoblom


Nicole Sjoblom
BS, Biochemistry
Stonehill College
Easton, MA
Biochemistry PhD Student
Rebecca Scheck, PhD, Adviser





Glycation is the spontaneous addition of sugar metabolites onto proteins. Also referred to as non-enzymatic glycosylation, glycation is a unique post-translational modification (PTM) that has been connected to several disorders including cancer, diabetes, and other age-related diseases. However, due to the non-enzymatic nature, glycation remains an obscure PTM. Based on the hypothesis that the local microenvironment, a combination of sequence and structure, is responsible for dictating the unique glycation outcome, my research is focused on a top-down proteomics approach to understand glycation. Ultimately, our lab hopes to generate chemical tools to manipulate glycation in vitro.

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