Student Publications


McGuire C, Stransky L, Cotter K, Forgac M. 2017. Regulation of V-ATPase actiity. Front Biosci. 22:609-622.  Abstract in PubMed

Patel AB, Tsilioni I, Weng Z, Theoharides TC. 2017. TNF stimulates IL-6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin. Exp Dermatol. Epub ahead of print.  Abstract in PubMed

Patel AB, Theoharides TC. 2017. Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J Pharmaol Exp Ther. 361: 462-471.   Abstract in PubMed

Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, Friedel RH, Hu GF. 2017. Plexin-B2 mediates physiologic and pathologic functions of angiogenin. Cell 171: 849-864. books


Coppage AL, Heard KR, DiMare MT, Liu Y, Wu W, Lai JH, Bachovchin WW. 2016. Human FGF-21 Is a substrate of fibroblast activation protein. PLoS One 11(3): e0151269.  books

Denis D, Rouleau C, Schaffhausen BS. 2016. A transformation-defective polyomavirus middle T antigen with a novel defect in PI3 kinase signaling. J Virol. 91(2). pii: e01774-16. Abstract in PubMed

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe. 21(2): 169-181. books

Metrick CM, Heldwein EE. 2016. The novel structure and unexpected RNA-binding ability of the C-terminal domain of HSV-1 tegument protein UL21. J Virol. 90(12): 5759-5769.  books

McGuire C, Cotter K, Stransky L, Forgac M. 2016. Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness. Biochim Biophys Acta. 1857(8): 1213-1218.  Abstract in PubMed

Patel AB, Tsilioni I, Leeman SE, Theoharides TC. 2016. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci USA. pii: 201604992.   Abstract in PubMed

Rogalin HB, Heldwein EE. 2016. Characterization of VSV pseudotypes bearing essential entry glycoproteins gB, gD, gH, and gL of Herpes Simplex virus Type 1. J Virol. 90(22): 10321-10328. books

Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. 2016. Transformation by Polyomavirus middle T antigen involve a unique bimodal interaction with the Hippo effector YAP. J Virol. 90: 7032-7045. Abstract in PubMed

Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. 2016. Targeting liver fibrosis with a cell-penetrating PAR2 pepducin. J Biol Chem. 291(44): 23188-23198. books

Theoharides TC, Tsilioni I, Patel AB, Doyle R. 2016. Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders. Transl Psychiatry. 6: e844.  Abstract in PubMed

Yang E, Cisowski J, Nguyen N, O'Callaghan K, Xu J, Agarwal A, Kuliopulos A, Covic L. 2016. Dysregulated protease activated receptor 1 (PAR1) promotes metastatic phenotype in breast cancer through HMGA2. Oncogene 35: 1529-40. books

Wong R, Feig LA. 2016. Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras. Biochem Biophys Res Commun. 480(3): 468-473.  books


Cotter K, Stransky L, McGuire C, Forgac M. 2015. Recent insights into the structure, regulation, and function of the V-ATPases. Trends Biochem Sci. 40: 611-622.   Abstract in PubMed

Metrick CM, Chadha P, Heldwein EE. 2015. The unusual fold of HSV-1 UL21, a multifunctional tegument protein. J Virol. 89: 2979-2984. books

Rogalin HB, Heldwein EE. 2015. The interplay between the HSV-1 gB cytodomains and the gH cytotail during cell-cell fusion. J Virol. 89: 12262-12272. books

Uzturk BG, Jin SX, Rubin B, Bartolome C, Feig LA. 2015. Ras-GRF1 regulates the HPA axis specifically in early-adolescent female mice. J Endocrinol. 227: 227-238.  Abstract in PubMed

Vanli N, Guo-Fu Hu. 2015. Mechanism and function of angiogenin in prostate cancer. Chinese J Biochem Mol Biol. 31: 1261-1266. books

Weng Z, Patel AB, Panagiotidou S, Theoharides TC. 2015. The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J Allergy Clin Immunol. 135: 1044-1052. Abstract in PubMed


Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. 2014. Polyoma small T antigen interacts with YES-Associated Protein (YAP) to regulate cell survival and differentiation. J Virol. 88: 12055-12064. Abstract in PubMed  (Correction: J Virol. 89: 6971)  Abstract in PubMed

Jin SX, Bartolome C, Arai JA, Hoffman L, Uzturk BG, Kumar-Singh R, Waxham MN, Feig LA. 2014. Domain contributions to signaling specificity differences between Ras-Guanine Nucleotide Releasing Factor (Ras-GRF)1 and Ras-GRF2. J Biol Chem. 289: 16551-16564. Abstract in PubMed

Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel EA, Kuperwasser C, Tsichlis PN. 2014. NDY1/KDM2B functions as a master regulator of Polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer Res. 74: 3935-3946. books

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. 2014. Phosphoproteomics screen reveals Akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell 53: 577-590. books

Stampfer SD, Heldwein EE. 2014. Expression, Purification, and Crystallization of HSV-1 Glycoproteins for Structure Determination. Methods Mol Biol. 1144: 249-263. books

Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. 2014. The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. PLoS Pathog. 10: e1004136. books

Weng Z, Patel AB, Vasiadi M, Therianou A, Theoharides TC. 2014. Luteolin inhibits human keratinocyte activation and decreases NF-κB induction that is increased in psoriatic skin. PLoS One 9: e90739. Abstract in PubMed


Connolly BA, O'Connell DP, Lamon-Fava S, Leblanc DF, Kuang YL, Schaefer EJ, Coppage AL, Benedict CR, Kiritsy CP, Bachovchin WW. 2013. The high-fat high-fructose hamster as an animal model for niacin's biological activities in humans. Metabolism 62: 1840-1849. books

Hwang JH, Jiang T, Kulkarni S, Faure N, Schaffhausen BS. 2013. Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt. J Biol Chem. 288: 32064-32073.books

McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. 2013. Akt regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One 8: e56576. books

Stampfer SD, Heldwein EE. 2013. Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry. Curr Opin Virol. 3: 13-19. books

Theoharides TC, Asadi S, Patel AB. 2013. Focal brain inflammation and autism. J Neuroinflammation. 10: 46. Abstract in PubMed

Vitu E, Sharma S, Stampfer SD, Heldwein EE. 2013. Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form. J Mol Biol. 425: 2056-2071. books


Everill P, Sudmeier JL, Bachovchin WW. 2012. Direct NMR observation and pKa determination of the Asp102 side chain in a serine protease. J Am Chem Soc. 134: 2348-2354. Abstract in PubMed

Ezell SA, Tsichlis PN. 2012. Akt1, EMSY, BRCA2 and type I IFN signaling: A novel arm of the IFN response. Transcription 3: 305-309. books

Ezell SA, Polytarchou C, Hatziapostolou M, Guo A, Sanidas I, Bihani T, Comb MJ, Sourvinos G, Tsichlis PN. 2012. The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Proc Natl Acad Sci USA. 109: E613-621. books

Ezeokonkwo C, Ghazy MA, Zhelkovsky A, Yeh P-C, Moore, C. Novel interactions at the essential N-terminus of poly(A) polymerase that could regulate poly(A) addition in Saccharomyces cerevisiae. FEBS Lett. 586: 1173-1178.  Abstract in PubMed

O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW. 2012. Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorg Med Chem Lett. 22: 1397-1401. Abstract in PubMed

Sims HI, Pham CD, Schnitzler GR. 2012. Mapping assembly favored and remodeled nucleosome positions on polynucleosomal templates. Methods Mol Bio. 833: 311-336. Abstract in PubMed

Wieschhaus A, Khan A, Zaidi A, Rogalin H, Hanada T, Liu F, De Franceschi L, Brugnara C, Rivera A, Chishti AH. 2012. Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. Biochem J. 448: 141-152. Abstract in PubMed

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research